Relationship between metabolic syndrome and nodular thyroid diseases

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dc.contributor.authorKır, Seher
dc.contributor.authorAydın, Yusuf
dc.contributor.authorCoşkun, Hülya
dc.date.accessioned2020-04-30T23:31:37Z
dc.date.available2020-04-30T23:31:37Z
dc.date.issued2018
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000424952600002en_US
dc.descriptionPubMed: 29141453en_US
dc.description.abstractNodular thyroid diseases are common in Turkey. Insulin resistance (IR) is considered as the most important component of metabolic syndrome (MetS), and it is thought to directly affect thyroid diseases, together with other components of MetS. The aim of this study was to evaluate potential factors associated with thyroid nodularity. This study was part of the prospective MELEN study. In total, randomly selected 2233 subjects were evaluated. A euthyroid subgroup of participants (n=1432) was selected and 421 of them had MetS. Both goitres and multinodular goitres (MNGs) were significantly more common in the MetS (+) group (p<.001). Older age was the only factor that significantly affected the presence of a nodular goitre (NG) (p<.001). The presence of a MNG was associated with older age (p<.001), systolic blood pressure level (p<.008) and MetS (p<.001). There was no difference in the thyroid volume or presence of nodular thyroid diseases between the IR (+) and (-) groups. Both the thyroid volume and the presence of MNGs were significantly associated with MetS, independent of thyroid-stimulating hormone (TSH) and IR. We suggest that the individual components of MetS may influence thyroid nodularity to some degree and that together they exert a cumulative effect on the thyroid gland. As a result, in the absence of MetS, we further suggest that IR alone does not explain the increase in thyroid volume and thyroid nodule formation.en_US
dc.description.sponsorshipDuzce University Scientific Research FundDuzce Universityen_US
dc.description.sponsorshipThis research is supported by Duzce University Scientific Research Fund.en_US
dc.identifier.doi10.1080/00365513.2017.1402363en_US
dc.identifier.endpage10en_US
dc.identifier.issn0036-5513
dc.identifier.issn1502-7686
dc.identifier.issue01.Feben_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage6en_US
dc.identifier.urihttps://doi.org/10.1080/00365513.2017.1402363
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4355
dc.identifier.volume78en_US
dc.identifier.wosWOS:000424952600002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofScandinavian Journal Of Clinical & Laboratory Investigationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNodular thyroid diseasesen_US
dc.subjectmetabolic syndromeen_US
dc.subjectinsulin resistanceen_US
dc.subjectgoitreen_US
dc.subjectthyroid volumeen_US
dc.titleRelationship between metabolic syndrome and nodular thyroid diseasesen_US
dc.typeArticleen_US

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