Evaluation of ocular findings in patients with lichen planus

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dc.contributor.authorÖzlü, Emin
dc.contributor.authorTeberik, Kuddusi
dc.date.accessioned2020-05-01T12:14:52Z
dc.date.available2020-05-01T12:14:52Z
dc.date.issued2019
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000472026600004en_US
dc.descriptionPubMed: 31333342en_US
dc.description.abstractIntroduction: Lichen planus (LP) is a chronic, inflammatory disease of unknown etiology. Aim: To evaluate the tear functions and the retinal and choroidal thickness (CT) in patients with LP. Material and methods: In total, 33 patients and 30 healthy controls were enrolled. All participants were evaluated using the Ocular Surface Disease Index (OSDI) questionnaire, Schirmer 1 test (with anesthesia), tear break-up time (TBUT) test, intraocular pressure (IOP), axial length (AL), and central corneal thickness (CCT). The measurements of retinal thickness (RT) and CT were obtained by spectral domain optical coherence tomography. Results: No significant difference was observed between the groups in IOP, AL, CCT, or RT (p > 0.05 in each group). There was a significant difference in the Schirmer 1 test, TBUT, and OSDI questionnaire (p < 0.05 in each group). Choroidal thickness in LP patients was thinner than that in the controls (p = 0.001 in each location). There was a moderate negative correlation between the disease duration and Schirmer 1 test, TBUT, and subfoveal CT (r = -0.426, r = -0.555, r = -0.637; p = 0.001, p = 0.001, p = 0.001, respectively). There was a moderate negative correlation between the oral mucosal involvement and Schirmer 1 test, TBUT, and subfoveal CT (r = -0.345, r = -0.392, r = -0.467; p = 0.006, p = 0.001, p = 0.001, respectively). There was a positive correlation between disease duration, oral mucosal involvement and OSDI score (r = 0.717, r = 0.345; p = 0.001, p = 0.006, respectively). Conclusions: Lichen planus may influence tear function tests and may cause dry eye. Patients with LP had lower CT values than healthy controls. Further studies are needed to clarify the effect of LP on the eyes.en_US
dc.identifier.doi10.5114/ada.2018.74464en_US
dc.identifier.endpage271en_US
dc.identifier.issn1642-395X
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage267en_US
dc.identifier.urihttps://doi.org/10.5114/ada.2018.74464
dc.identifier.urihttps://hdl.handle.net/20.500.12684/6370
dc.identifier.volume36en_US
dc.identifier.wosWOS:000472026600004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTermedia Publishing House Ltden_US
dc.relation.ispartofPostepy Dermatologii I Alergologiien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcorneaen_US
dc.subjectchoroiden_US
dc.subjecteyeen_US
dc.subjectlichen planusen_US
dc.subjecttearsen_US
dc.titleEvaluation of ocular findings in patients with lichen planusen_US
dc.typeArticleen_US

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