Arterial Stiffness and Subclinical Inflammation in Children with Familial Mediterranean Fever: A Comprehensive Analysis

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dc.authoridSav, Nadide Melike/0000-0003-1520-6426;
dc.contributor.authorSav, Nadide Melike
dc.contributor.authorAltinsoy, Hasan Baki
dc.contributor.authorTuren, Betul
dc.contributor.authorGokce, Ayse
dc.date.accessioned2025-10-11T20:47:48Z
dc.date.available2025-10-11T20:47:48Z
dc.date.issued2025
dc.departmentDüzce Üniversitesien_US
dc.description.abstractBackground/Objectives: Familial Mediterranean fever (FMF) is a chronic autoinflammatory disease. Throughout the disease, subclinical inflammation persists into the remission period. It is known that chronic inflammation causes endothelial dysfunction and, as a consequence, arterial stiffness occurs. In this study, carotid and aortic intima-media thicknesses (IMT) and arterial stiffness were measured in FMF patients to evaluate the risk of possible vascular damage due to chronic inflammation. Methods: The study included pediatric patients with FMF who had been in remission for a minimum of 3 months. Carotid and aortic IMT and arterial stiffness measurements were conducted using sonoelastography. The acute-phase reactants were also evaluated in all participants. Results: Carotid artery stiffness measurements by strain elastography were significantly higher in the patient group than in the control group. However, the aortic and carotid IMT were similar between the two groups. The acute-phase reactants were significantly higher in the patient group than in the control group. Conclusions: This study demonstrated that arterial stiffness increased in pediatric FMF patients. According to the results of the present study, the effects of chronic inflammation on arterial tissues may lead to atherosclerotic changes in the later stages of the disease and may pose a risk for coronary diseases. Arterial ultrasonographic and elastographic measurements to be performed periodically in children with FMF are noninvasive methods that can be used to evaluate the course of endothelial damage. We aimed to show that arterial stiffness may be a marker of early cardiovascular disease.en_US
dc.identifier.doi10.3390/children12020232
dc.identifier.issn2227-9067
dc.identifier.issue2en_US
dc.identifier.pmid40003334en_US
dc.identifier.scopus2-s2.0-85219197927en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.3390/children12020232
dc.identifier.urihttps://hdl.handle.net/20.500.12684/21582
dc.identifier.volume12en_US
dc.identifier.wosWOS:001429663700001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofChildren-Baselen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_WOS_20250911
dc.subjectarterial stiffnessen_US
dc.subjectchildrenen_US
dc.subjectfamilial mediterranean feveren_US
dc.subjectinflammationen_US
dc.subjectintima-media thicknessen_US
dc.subjectreal-time tissue elastographyen_US
dc.titleArterial Stiffness and Subclinical Inflammation in Children with Familial Mediterranean Fever: A Comprehensive Analysisen_US
dc.typeArticleen_US

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