The Evaluation of Argyrophilic Nucleolar Organizing Region Proteins in Fine-Needle Aspiration Samples of Thyroid

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dc.contributor.authorEröz, Recep
dc.contributor.authorCücer, Nurhan
dc.contributor.authorKaraca, Züleyha
dc.contributor.authorÜnlühizarcı, Kürşad
dc.contributor.authorÖztürk, Figen
dc.date.accessioned2020-04-30T23:33:38Z
dc.date.available2020-04-30T23:33:38Z
dc.date.issued2011
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000291220600004en_US
dc.descriptionPubMed: 21556738en_US
dc.description.abstractArgyrophilic nucleolar organizing region associated proteins (AgNORs) have been shown to be of interest in a variety of different diseases including thyroid disorders. Our aim was to distinguish benign thyroid lesions from papillary thyroid carcinoma (PTC) via AgNOR count and with a new approach, via AgNOR surface area/total nuclear surface area (NORa/TNa) proportions in the nuclei on fine-needle aspiration (FNA) materials. Thirty patients (eight men and 22 women) whose FNA was compatible with benign lesion and 26 patients (eight men and 18 women) whose FNA was compatible with PTC were included in the study. Fine-needle aspiration materials were stained for AgNOR detection according to a specific protocol. One hundred nuclei per individual have been evaluated, and AgNOR number and NORa/TNa proportions of individual cells were measured and calculated by using a computer program. Patients with PTC had significantly (p < 0.001) higher AgNOR count (4.6 +/- 1.2%) than in the patients with benign lesions (2.0 +/- 0.5%). Additionally, patients with PTC had significantly (p < 0.001) higher NORa/TNa (13.4 +/- 2.4) than in the patients with benign lesion (5.7 +/- 1.0). Modified method of AgNOR staining is an easy and reliable method for evaluating proliferation activity of cells in malignant and benign thyroid lesions and it may contribute to routine cytopathology in inconclusive situations.en_US
dc.description.sponsorshipErciyes UniversityErciyes University [B-538]en_US
dc.description.sponsorshipThe Medical Research Council of Erciyes University (ERUBAP, Project No. B-538) supported this work.en_US
dc.identifier.doi10.1007/s12022-011-9161-zen_US
dc.identifier.endpage78en_US
dc.identifier.issn1046-3976
dc.identifier.issn1559-0097
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage74en_US
dc.identifier.urihttps://doi.org/10.1007/s12022-011-9161-z
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5013
dc.identifier.volume22en_US
dc.identifier.wosWOS:000291220600004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherHumana Press Incen_US
dc.relation.ispartofEndocrine Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNORen_US
dc.subjectAgNORsen_US
dc.subjectThyrocyteen_US
dc.subjectrDNAen_US
dc.titleThe Evaluation of Argyrophilic Nucleolar Organizing Region Proteins in Fine-Needle Aspiration Samples of Thyroiden_US
dc.typeArticleen_US

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