The Relationship of Hepcidin, Soluble Transferrin Receptor, Growth Differentiation Factor-15 And Anemia in Multipl Myeloma

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dc.authoridkos, durdu mehmet/0000-0002-2371-7675en_US
dc.authoridSungur, Mehmet Ali/0000-0001-5380-0819en_US
dc.authoridÖneç, Birgül/0000-0003-2824-1044en_US
dc.authorwosidkos, durdu mehmet/H-6792-2018en_US
dc.authorwosidSungur, Mehmet Ali/K-9052-2015en_US
dc.authorwosidÖneç, Birgül/AAA-2012-2021en_US
dc.contributor.authorOnec, Birgul
dc.contributor.authorKos, Durdu Mehmet
dc.contributor.authorAltun, Gulsah
dc.contributor.authorSungur, Mehmet Ali
dc.date.accessioned2024-08-23T16:03:50Z
dc.date.available2024-08-23T16:03:50Z
dc.date.issued2023en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractObjective: Multiple myeloma (MM) is a malignant hematological disease and anemia is observed in the majority of patients. Hepcidin, Growth differentiation factor-15 (GDF-15), soluble transferrin receptor (sTfR) have been investigated in many forms of anemia, especially in chronic diseases and cancers. However, there are few studies investigating their role in MM. We aimed to determine the relationship between hepcidin, sTfR and GDF-15 levels in MM patients and their clinical features such as anemia parameters, disease stage and overall survival.Methods: Hepcidin, sTfR and GDF-15 levels, as well as clinical and anemia-related parameters, were analyzed in newly diagnosed MM patients and healthy volunteers.Results: Although MM patients had significantly lower Hb and Hct levels compared to the control group, none of the GDF-15, hepcidin and sTfR levels showed a significant difference between the groups. Among MM patients, we found that the anemic subgroup had significantly lower hepcidin levels than the non-anemic subgroup. GDF-15, hepcidin and sTfR levels showed weak or moderate, but statistically significant positive correlation with each other, while GDF15 was positively correlated with creatinine and sTfR levels were correlated with many parameters such as LDH, CRP, ferritin, albumin, creatinine, Hb and ISS, all of which weak. None of the levels of GDF-15, hepcidin and sTfR had a significant effect on survival.Conclusions: We suggested that these mediators may play a role in anemia of MM but there is not a clear relashionship as in chronic disease anemia, there may be different mechanisms according to the characteristics of the patient groups.en_US
dc.identifier.doi10.18521/ktd.1321364
dc.identifier.endpage376en_US
dc.identifier.issn1309-3878
dc.identifier.issue3en_US
dc.identifier.startpage369en_US
dc.identifier.trdizinid1203074en_US
dc.identifier.urihttps://doi.org/10.18521/ktd.1321364
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1203074
dc.identifier.urihttps://hdl.handle.net/20.500.12684/13932
dc.identifier.volume15en_US
dc.identifier.wosWOS:001099802900014en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherDuzce Univ, Fac Medicineen_US
dc.relation.ispartofKonuralp Tıp Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMultiple Myelomaen_US
dc.subjectAnemiaen_US
dc.subjectHepcidinen_US
dc.subjectGrowth Differentiation Factor-15 (GDF-15)en_US
dc.subjectSoluble Transferrin Receptoren_US
dc.subjectMacrophage Inhibitory Cytokine-1en_US
dc.subjectExpressionen_US
dc.subjectGdf15en_US
dc.titleThe Relationship of Hepcidin, Soluble Transferrin Receptor, Growth Differentiation Factor-15 And Anemia in Multipl Myelomaen_US
dc.typeArticleen_US

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