High levels of high-sensitivity C-reactive protein and uric acid can predict disease severity in patients with mitral regurgitation

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dc.contributor.authorTürker, Yasin
dc.contributor.authorEkinözü, İsmail
dc.contributor.authorTürker, Yasemin
dc.contributor.authorAkkaya, Mehmet
dc.date.accessioned2020-05-01T12:10:21Z
dc.date.available2020-05-01T12:10:21Z
dc.date.issued2014
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000345814000005en_US
dc.descriptionPubMed: 25448796en_US
dc.description.abstractIntroduction: Both high-sensitivity CRP (hs-CRP) and uric acid (UA) levels are known to be increased in heart failure patients and are associated with poorer functional capacity and adverse outcome. The role of these markers in patients with mitral regurgitation (MR) is less clear. The aim of this study was to assess the relationship between hs-CRP, UA and organic MR. We also assessed whether hs-CRP and UA levels are correlated with symptoms of MR, severity of MR, LV remodeling and outcome during follow-up. Methods: A total of 200 consecutive patients (87 men [43.5%]; mean age 61.6 +/- 12.5 years) with moderate or severe isolated and organic MR were included in the study. All the patients were assessed clinically and were managed and treated with standard medical therapy according to evidence-based practice guidelines. Patients were categorized according to New York Heart Association (NYHA) functional class. We assessed and graded the severity of MR using a multiparametric approach. hs-CRP was measured with chemiluminescent immunometric assay using an IMMULITE (R) 1000 autoanalyzer (Siemens, Germany). Serum UA levels were analyzed using a Cobas (R) 6000 autoanalyzer (Roche Diagnostics, Mannheim, Germany). Results: Mean UA levels increased significantly with NYHA class: 4.46 +/- 1.58 mg/dl for patients in NYHA class I, 5.91 +/- 1.69 mg/dl for class II, 6.31 +/- 2.16 mg/dl for class III and 8.86 +/- 3.17 mg/dl for class IV (p<0.001). Mean UA levels also increased significantly with increased severity of MR (moderate 5.62 +/- 1.9 mg/dl, moderate to severe 5.56 +/- 1.2 mg/dl, severe 7.38 +/- 3.4 mg/dl, p<0.001). There was a significant correlation between UA level and left ventricular end-diastolic diameter (r=0.40; p<0.001), left ventricular end-systolic diameter (r=0.297; p=0.001) and left ventricular ejection fraction (LVEF) (r=0.195, p=0.036), whereas hs-CRP was not correlated with these parameters. In multivariate Cox proportional hazards analysis LVEF, NYHA class and UA levels were the only independent predictors of death. Conclusion: UA and hs-CRP levels can help identify patients with asymptomatic moderate or severe mitral regurgitation. UA levels may be useful to assess the extent of left ventricular remodeling and in the optimal timing of mitral valve surgery in certain subsets of patients. (C) 2013 Sociedade Portuguesa de Cardiologia. Published by Elsevier Espana, S.L.U. All rights reserved.en_US
dc.identifier.doi10.1016/j.repc.2014.03.014en_US
dc.identifier.endpage706en_US
dc.identifier.issn0870-2551
dc.identifier.issn0304-4750
dc.identifier.issue11en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage699en_US
dc.identifier.urihttps://doi.org/10.1016/j.repc.2014.03.014
dc.identifier.urihttps://hdl.handle.net/20.500.12684/6154
dc.identifier.volume33en_US
dc.identifier.wosWOS:000345814000005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Doyma Slen_US
dc.relation.ispartofRevista Portuguesa De Cardiologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHigh-sensitivity C-reactive proteinen_US
dc.subjectMitral regurgitationen_US
dc.subjectNYHA classen_US
dc.subjectUric aciden_US
dc.titleHigh levels of high-sensitivity C-reactive protein and uric acid can predict disease severity in patients with mitral regurgitationen_US
dc.typeArticleen_US

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