Assessment of diagnostic value of preoperative elastography in thyroid nodules having indeterminate cytology results

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dc.authoridŞahin, Mustafa/0000-0002-4718-0083
dc.authoridDüğer, Hakan/0000-0001-5478-3192
dc.authoridSencar, Muhammed Erkam/0000-0001-5581-4886
dc.authoridcakal, erman/0000-0003-4455-7276
dc.authorwosidKizilgul, Muhammed/HLH-5249-2023
dc.authorwosidŞahin, Mustafa/AAH-3394-2019
dc.authorwosidÖnal, Binnur/AFD-8096-2022
dc.authorwosidDüğer, Hakan/GPK-6118-2022
dc.contributor.authorUçan, Bekir
dc.contributor.authorŞahin, Mustafa
dc.contributor.authorÖnal, Binnur
dc.contributor.authorKizilgul, Muhammed
dc.contributor.authorDuger, Hakan
dc.contributor.authorSencar, Muhammed Erkam
dc.contributor.authorÇakal, Erman
dc.date.accessioned2023-07-26T11:50:34Z
dc.date.available2023-07-26T11:50:34Z
dc.date.issued2021
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalıen_US
dc.description.abstractBackground/aim: The management of nodules with indeterminate cytology [atypia of undetermined significance (AUS), follicular lesion of undetermined significance (FLUS), follicular neoplasm (FN), suspicious for a follicular neoplasm (SFN), and suspicious for malignancy (SM)] results is controversial. To assess the role of the elastography technique in the diagnosis of malignancy in the subtypes of indeterminate thyroid nodules. Materials and methods: We included 132 patients with indeterminate cytology who underwent thyroid surgery. Sensitivity, specificity, area under the curve, and optimal cut-off points were calculated with receiver operating characteristic (ROC) analysis for elastography score (ES) and strain index (SI). Results: Malignancy was observed in 27/95 (28.4%) of the AUS-FLUS cytology and 12/24 (50%) of FN, SFN cytology. All of the 13 patients (100 %) with SM are found to be malignant on histology. In the FLUS group, nodules with ES greater or equal to 3, the presence of malignancy was higher 17/41 (41.5%) when compared with nodules with ES smaller than 39/46 (19.6 %) (p = 0.023). In the SFN group, 2 of 2 nodules with an ES score of 4 and 1 of 1 nodule with an ES score of 5 were malignant. In the FLUS group, 4 of 10 nodules with an ES score of 4 and 2 of 2 nodules with an ES score of 5 were malignant. Conclusion: Thyroid elastography may reduce unnecessary surgery for both patients with AUS/FLUS and selected SFN cytology. Elastography appears to be helpful in follicular variants and other types of papillary thyroid cancer, however, not in follicular thyroid cancer.en_US
dc.identifier.doi10.3906/sag-2101-246
dc.identifier.endpage2930en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue6en_US
dc.identifier.pmid34289651en_US
dc.identifier.scopus2-s2.0-85122973549en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage2924en_US
dc.identifier.urihttps://doi.org/10.3906/sag-2101-246
dc.identifier.urihttps://hdl.handle.net/20.500.12684/12378
dc.identifier.volume51en_US
dc.identifier.wosWOS:000731456300015en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorÖnal, Binnur
dc.language.isoenen_US
dc.publisherScientific and Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectElastography; Indeterminate Cytology; Malignancy; Thyroiden_US
dc.subjectFine-Needle-Aspiration; Undetermined Significance; Association Guidelines; Bethesda System; Ultrasonography; Expression; Malignancy; Management; Atypiaen_US
dc.titleAssessment of diagnostic value of preoperative elastography in thyroid nodules having indeterminate cytology resultsen_US
dc.typeArticleen_US

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