Comparative Evaluation of Common Comorbidity Scores and Freiburger Comorbidity Index as Prognostic Variables in a Real Life Multiple Myeloma Population

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dc.contributor.authorÖneç, Birgul
dc.contributor.authorOkutan, Harika
dc.contributor.authorAlbayrak, Murat
dc.contributor.authorCan, Esra Sarıbacak
dc.contributor.authorAslan, Vedat
dc.contributor.authorKösemehmetoğlu, Özge Soyer
dc.contributor.authorKoluman, Başak Ünver
dc.date.accessioned2020-04-30T22:41:06Z
dc.date.available2020-04-30T22:41:06Z
dc.date.issued2016
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionalbayrak, murat/0000-0003-4025-741Xen_US
dc.descriptionWOS: 000386685400009en_US
dc.descriptionPubMed: 27812251en_US
dc.description.abstractMultiple myeloma (MM) is a disease of the geriatric population with a median age at diagnosis of 69 years but most clinicians consider performance status and comorbidities rather than chronological age in determining prognosis and treatment. The purpose of this study was to assess whether and which comorbidity indices predict survival in a real life population of MM. We calculated Charlson Comorbidity Index (CCI), age combined Charlson index (CCI-age), Hematopoietic cell transplantation-specific comorbidity index (HCT-SCI) and Freiburger comorbidity index (FCI) retrospectively for 66 MM patients and compared their impact on treatment responses and overall survival (OS). Treatment response was significantly worse in groups with high CCI, CCI-age, HCT-SCI scales (p < 0.05), but FCI's effect on treatment response was not significant. However, while no significant relationship was determined between other comorbidity indices with OS, it was related only with FCI-CI (p = 0.006). FCI, developed in this patient group, was the only prognostic index with a significant effect on OS in the evaluation of comorbidities in MM patients with different scores, but its relationship to treatment responses was not significant contrary to other indices. While this small patient group gave us hope regarding the use of FCI in practice, multi-center studies are still required.en_US
dc.identifier.doi10.1007/s12288-015-0618-yen_US
dc.identifier.endpage430en_US
dc.identifier.issn0971-4502
dc.identifier.issn0974-0449
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage424en_US
dc.identifier.urihttps://doi.org/10.1007/s12288-015-0618-y
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3124
dc.identifier.volume32en_US
dc.identifier.wosWOS:000386685400009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringer Indiaen_US
dc.relation.ispartofIndian Journal Of Hematology And Blood Transfusionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectComorbidity scoresen_US
dc.subjectFreiburger comorbidity indexen_US
dc.subjectMultiple myelomaen_US
dc.subjectPrognosisen_US
dc.subjectSurvivalen_US
dc.subjectTreatment responseen_US
dc.titleComparative Evaluation of Common Comorbidity Scores and Freiburger Comorbidity Index as Prognostic Variables in a Real Life Multiple Myeloma Populationen_US
dc.typeArticleen_US

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