Can Numeric Maturation Value Be Used as a Prognostic Indicator and Diagnostic Tool in Cutaneous Melanomas? A Morphometric Study

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dc.contributor.authorGamsızkan, Mehmet
dc.contributor.authorBüyücek, Şeyma
dc.contributor.authorCoşkun, Sinem Kantarcıoğlu
dc.contributor.authorSungur, Mehmet Ali
dc.contributor.authorÖzlü, Emin
dc.contributor.authorBahçıvan, Atike
dc.contributor.authorÖnal, Binnur
dc.date.accessioned2020-04-30T22:40:28Z
dc.date.available2020-04-30T22:40:28Z
dc.date.issued2019
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000502985200004en_US
dc.description.abstractOBJECTIVE: Some melanocytic lesions can be difficult to diagnose because of ambiguous histological and immunohistochemical features. Morphometric features of melanocytes in the upper and lower parts of a challenging lesion may help to facilitate an accurate diagnosis. STUDY DESIGN: We studied 32 cases of invasive cutaneous melanoma, 35 cases of mild or moderate dysplastic nevus, and 31 cases of benign melanocytic nevus. All cases were immunostained with Sox10. The nuclear areas of 30 melanocytes were measured on each papillary (upper al1) dermis and reticular dermis/subcutaneous tissue (lower ILI) in all cases by using the Image J analysis program. Then, a maturation index (U/L) was calculated for each case. Also, cutaneous melanomas were categorized into 2 groups that displayed pseudo-maturation or the lack of it. RESULTS: Mean maturation index was 1.04 +/- 0.29 in melanomas, 1.23 +/- 0.28 in dysplastic nevi, and 1.52 +/- 0.33 in benign melanocytic nevi, respectively. There were statistically significant differences between melanoma and dysplastic nevus (p = 0.012) and between melanoma and benign melanocytic nevus (p < 0.001) for the maturation index. Although pseudo-maturation was associated with low mitotic activity and thin Breslow thickness, there was no significant difference between survival distributions of 2 melanoma groups. CONCLUSION: Calculation of the maturation index can be used as a supporting tool for the differential diagnosis of challenging cases. However, it may possess limitation for evaluation of nevoid melanoma, melanoma in situ, or clonal nevus.en_US
dc.identifier.endpage183en_US
dc.identifier.issn0884-6812
dc.identifier.issue5en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage177en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/2989
dc.identifier.volume41en_US
dc.identifier.wosWOS:000502985200004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSci Printers & Publ Incen_US
dc.relation.ispartofAnalytical And Quantitative Cytopathology And Histopathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbiomarkersen_US
dc.subjecttumoren_US
dc.subjectdiagnosisen_US
dc.subjectimmunohistochemistryen_US
dc.subjectmaturationen_US
dc.subjectmelanocytesen_US
dc.subjectmelanomaen_US
dc.subjectmorphometryen_US
dc.subjectnevusen_US
dc.subjectmelanocyticen_US
dc.subjectSchwann cellsen_US
dc.subjectskinen_US
dc.subjectskin neoplasmsen_US
dc.subjectSox10 proteinen_US
dc.subjecthumanen_US
dc.subjectSox10 transcription factoren_US
dc.titleCan Numeric Maturation Value Be Used as a Prognostic Indicator and Diagnostic Tool in Cutaneous Melanomas? A Morphometric Studyen_US
dc.typeArticleen_US

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