Lifestyle modification decreases the mean platelet volume in prehypertensive patients

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dc.contributor.authorYazıcı, Mehmet
dc.contributor.authorKaya, Ahmet
dc.contributor.authorKaya, Yasemin
dc.contributor.authorAlbayrak, Sinan
dc.contributor.authorCinemre, Hakan
dc.contributor.authorÖzhan, Hakan
dc.date.accessioned2020-04-30T23:18:55Z
dc.date.available2020-04-30T23:18:55Z
dc.date.issued2009
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000262790000010en_US
dc.descriptionPubMed: 19172523en_US
dc.description.abstractMean platelet volume (MPV) is an indicator of platelet activation. The present study was designed to investigate platelet function by measuring MPV, platelet count (PLC) and platelet mass (PLM) in prehypertensive (PHT) subjects. Additionally, we also evaluated the effects of lifestyle modification on platelet functions by measuring MPV, PLC and PLM. We selected 36 newly diagnosed PHT patients and 21 control subjects (BP 120/80 mmHg) matched for age and sex. Lifestyle modifications (weight loss, reduced sodium intake, increased physical activity, limited alcohol consumption and the Dietary Approaches to Stop Hypertension (DASH) diet) were recommended to PHT individuals for 20 weeks. At entry into the study, although PLM and PLC values were similar between study groups, MPV values were significantly higher in the PHT group than in the control group (respectively, 10.41 0.93 fl vs. 9.56 1.04 fl, p 0.01). Additionally, MPV was positively correlated with the systolic blood pressure (BP), body mass index (BMI) and insulin resistance (IR) in the PHT group (r: 0.41; p 0.02, r: 0.37; p 0.04, r: 0.35; p 0.05, respectively). Only age and PHT were found to be independent predictors of MPV after regression analysis. The program substantially lowered BP (net reductions in systolic and diastolic BPs of 16.2 and 8.7 mmHg, p 0.001, p 0.001, respectively). In addition, BMI, waist circumference (WC) and IR were significantly reduced in the PHT group (p 0.01, p 0.01, p 0.05, respectively). At the end of study, although PLM, PLC values were reduced in the PHT group, only the decrease in MPV reached statistical significance (respectively, 10.41 0.93 fl vs. 9.67 1.2 fl, p 0.01). In closing, to our best notice, our study is the first to display a significant increase in MPV in PHT subjects and to show a decrease in MPV by lifestyle modification after 20 weeks. As a result, we consider that decreased platelet activation with multi-aspect effects of lifestyle modification therapy might play an important role in reducing thrombotic risk in PHT patients.en_US
dc.identifier.doi10.1080/09537100802613449en_US
dc.identifier.endpage63en_US
dc.identifier.issn0953-7104
dc.identifier.issn1369-1635
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage58en_US
dc.identifier.urihttps://doi.org/10.1080/09537100802613449
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3583
dc.identifier.volume20en_US
dc.identifier.wosWOS:000262790000010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofPlateletsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPrehypertensionen_US
dc.subjectlifestyle modificationen_US
dc.subjectplatelet functionen_US
dc.titleLifestyle modification decreases the mean platelet volume in prehypertensive patientsen_US
dc.typeArticleen_US

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