Aortic stiffness increases in proportion to the severity of apnoea-hypopnea index in patients with obstructive sleep apnoea syndrome

Basit Öğe Kaydı
dc.contributor.authorÇörtük, Mustafa
dc.contributor.authorAkyol, Selahattin
dc.contributor.authorBaykan, Ahmet O.
dc.contributor.authorKiraz, Kemal
dc.contributor.authorUçar, Hakan
dc.contributor.authorÇaylı, Murat
dc.contributor.authorKandiş, Hayati
dc.date.accessioned2020-04-30T22:39:31Z
dc.date.available2020-04-30T22:39:31Z
dc.date.issued2016
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000379940400007en_US
dc.descriptionPubMed: 25401950en_US
dc.description.abstractBackground and AimsObstructive sleep apnoea syndrome (OSA) and aortic stiffness are associated with an increased risk of cardiovascular morbidity and mortality. Although aortic stiffness increased in patients with OSA, the relationship between severity of OSA indicated with apnoea-hypopnea index (AHI) and aortic stiffness was not investigated in previous studies. The aim of this study is to investigate the relationship between the severity of OSA and aortic stiffness. MethodsIn the present study, 90 consecutive OSA patients definite diagnosed with sleep test were prospectively included (mean age 54.511.6 years). Aortic pulse wave velocity (PWV) and augmentation index (AIx) were calculated using the single-point method via the Mobil-O-Graph (R) ARCsolver algorithm. Aortic distensibility (AD) was calculated from the echocardiographically derived ascending aorta diameters and haemodynamic pressure measurements. Overnight full-laboratory polysomnography examination was conducted on each subject. Patients were classified into two groups according to their median AHI values (AHI(low) and AHI(high) groups). ResultsPWV values were higher and AD values were lower in AHIhigh group compared with AHIlow group (P<0.05, for all). AHI was associated with body mass index (BMI), systolic blood pressure, pulse pressure, aortic diameter, AD, AIx and PWV in bivariate analysis (P<0.05, for all). Multivariate linear regression analysis showed that AHI was independently associated with BMI (=0.175, P=0.047), PWV (=0.521, P<0.001) and aortic distensibility (=-0.223, P=0.020). ConclusionsAortic stiffness is associated both with the presence and the severity of OSA.en_US
dc.identifier.doi10.1111/crj.12244en_US
dc.identifier.endpage461en_US
dc.identifier.issn1752-6981
dc.identifier.issn1752-699X
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage455en_US
dc.identifier.urihttps://doi.org/10.1111/crj.12244
dc.identifier.urihttps://hdl.handle.net/20.500.12684/2749
dc.identifier.volume10en_US
dc.identifier.wosWOS:000379940400007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofClinical Respiratory Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectaortaen_US
dc.subjectobstructive sleep apnoeaen_US
dc.subjectpulse wave velocityen_US
dc.subjectvascular stiffnessen_US
dc.titleAortic stiffness increases in proportion to the severity of apnoea-hypopnea index in patients with obstructive sleep apnoea syndromeen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
2749.pdf
Boyut:
147.48 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu