Hyperbaric oxygen therapy attenuates urethral stricture formation after urethral injury: an experimental rabbit study

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dc.contributor.authorDanis, Hasan
dc.contributor.authorYuksel, Alpaslan
dc.contributor.authorBaba, Dursun
dc.contributor.authorSenoglu, Yusuf
dc.contributor.authorTaskiran, Arda Taskin
dc.contributor.authorBasaran, Ekrem
dc.contributor.authorTekin, Ali
dc.date.accessioned2026-07-01T11:40:14Z
dc.date.available2026-07-01T11:40:14Z
dc.date.issued2026
dc.departmentDüzce Üniversitesi
dc.description.abstractPurpose Urethral stricture (US) is a frequent and challenging urological entity characterized by spongiofibrosis and luminal narrowing, often leading to recurrent infections, urinary retention, and upper tract deterioration. Despite various endoscopic and open surgical options, high recurrence rates remain a major problem, and there is no established medical therapy to prevent stricture formation. To investigate the protective effect of hyperbaric oxygen (HBO) therapy on fibrosis and stricture formation in an experimental urethral injury model in rabbits using objective endoscopic, radiologic, and histopathologic parameters. Methods Twenty-eight male New Zealand rabbits were randomized into three groups: sham (n = 8), urethral injury without treatment (control, n = 10), and urethral injury plus HBO (HBO, n = 10). Among the 20 rabbits with urethral injury, allocation to the untreated control group (Group 2) and the HBO treatment group (Group 3) was performed in a 1:1 ratio using a computer-generated randomization list. Standardized circumferential electrocoagulation was applied to the bulbar urethra in the control and HBO groups. HBO was administered at 2 ATA, 90 min/day for 21 consecutive days starting on the day of injury. On day 28, all animals underwent urethroscopy and retrograde urethrography; urethral specimens were then harvested for histopathological evaluation. Fibrosis was graded (0-3) using Masson trichrome staining. Results Normal urethral diameters were similar among the groups (p = 0.604). Median stricture diameter was significantly lower in the untreated control group compared with the HBO and sham groups (2.15 mm vs. 8.05 mm and normal segment, respectively; p < 0.001). Median percentage urethral narrowing was 78.52% in the control group and 23.51% in the HBO group (p < 0.001). Fibrosis scores were significantly higher in the control group than in the HBO and sham groups (p < 0.001). Conclusion HBO therapy significantly attenuated fibrosis and urethral narrowing in this experimental urethral injury model. These findings suggest that HBO may represent a promising adjuvant strategy to prevent US formation after urethral trauma, warranting further clinical investigation.
dc.identifier.doi10.1007/s00345-026-06323-2
dc.identifier.issn0724-4983
dc.identifier.issn1433-8726
dc.identifier.issue1
dc.identifier.orcid0000-0002-4779-6777
dc.identifier.pmid41779155
dc.identifier.scopus2-s2.0-105031931892
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1007/s00345-026-06323-2
dc.identifier.urihttps://hdl.handle.net/20.500.12684/23708
dc.identifier.volume44
dc.identifier.wosWOS:001712649500002
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofWorld Journal of Urology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260623
dc.subject[Keyword Not Available]
dc.titleHyperbaric oxygen therapy attenuates urethral stricture formation after urethral injury: an experimental rabbit study
dc.typeArticle

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