The Effects of Long-term Growth Hormone Treatment on Ocular Findings

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dc.authoridAnkaralı, Handan/0000-0002-3613-0523en_US
dc.authoridAnkarali, Handan Camdeviren/0000-0002-3613-0523en_US
dc.authorscopusid57196037801en_US
dc.authorscopusid24399934200en_US
dc.authorscopusid55346675800en_US
dc.authorscopusid23134564000en_US
dc.authorscopusid58037173100en_US
dc.authorscopusid6603074686en_US
dc.authorwosidAnkaralı, Handan/HTN-2985-2023en_US
dc.authorwosidAnkarali, Handan Camdeviren/P-1058-2016en_US
dc.contributor.authorEski, Mehmet Tahir
dc.contributor.authorTeberik, Kuddusi
dc.contributor.authorBolu, Semih
dc.contributor.authorAnkarali, Handan
dc.contributor.authorKaya, Murat
dc.contributor.authorArslanoglu, Ilknur
dc.date.accessioned2024-08-23T16:04:30Z
dc.date.available2024-08-23T16:04:30Z
dc.date.issued2023en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractPurpose This study aimed to examine the long-term changes in anterior chamber depth (ACD), central corneal thickness (CCT), axial length (AxL), peripapillary retinal nerve fibre layer thickness (RNFLT), peripapillary ganglion cell layer - inner plexiform layer (GCL-IPL) thickness, and peripapillary choroidal thickness (ChT) after rhGH replacement treatment in paediatric patients with IGHD, compared to healthy controls.Methods Twenty-two children with IGHD including 12 girls and 10 boys were enrolled in the study group, and 30 (16 girls, 14 boys) healthy children composed the control group. A detailed ophthalmological examination was performed for each participant. ACD, CCT, AxL, peripapillary RNFLT, GCL-IPL thickness and ChT measurements were performed before the rhGH replacement treatment and in the 12th month of the post-treatment period, as well as the corresponding visits in the control group. AxL ultrasound pachymetry (CCT), peripapillary RNFL thickness, peripapillary RNFLT, GCL-IPL thickness, and peripapillary ChT parameters were measured by spectral-domain optical coherence tomography.Results The mean age of the groups were similar (p = 0.143). 12-month CCT, ACD, and AxL measurements of the study group showed significantly higher results than the pre-treatment measurements (p = 0.005, p = 0.024, and p = 0.002, respectively). Similarly, the mean RNFLT and ChT measurements of the study group obtained from all sectors were significantly higher in the 12th-month visit (p < 0.001 for both) other than the RNFLT, and GCL-IPL thickness measurements (p > 0.05 for all). However, all these parameters were similar at pre- and post-treatment visits in the control group (p > 0.05 for all). The mean pre-treatment values of all these parameters were significantly lower in the study group compared to the control group (p < 0.05 for all), other than the RNFLT, GCL-IPL thickness measurements (p > 0.05 for all), while the mean post-treatment values of all these parameters in both groups were similar at month 12 (p > 0.05 for all).Conclusion GH replacement treatment in childhood may play an important role in the development of the neural retina and can be effective on the anterior segment, RNFLT and ChT measurements.en_US
dc.identifier.doi10.1055/a-2040-4144
dc.identifier.endpage1003en_US
dc.identifier.issn0023-2165
dc.identifier.issn1439-3999
dc.identifier.issue8en_US
dc.identifier.pmid37015252en_US
dc.identifier.scopus2-s2.0-85160757731en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage997en_US
dc.identifier.urihttps://doi.org/10.1055/a-2040-4144
dc.identifier.urihttps://hdl.handle.net/20.500.12684/14235
dc.identifier.volume240en_US
dc.identifier.wosWOS:000964353500003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGeorg Thieme Verlag Kgen_US
dc.relation.ispartofKlinische Monatsblatter Fur Augenheilkundeen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcongenital isolated growth hormone deficiencyen_US
dc.subjectrecombinant growth hormoneen_US
dc.subjectretina nerve fiber layer thicknessen_US
dc.subjectspectral-domain optical coherence tomographyen_US
dc.subjectIgf-Ien_US
dc.subjectChildrenen_US
dc.subjectGhen_US
dc.subjectDeficiencyen_US
dc.subjectThicknessen_US
dc.subjectRetinaen_US
dc.subjectPrevalenceen_US
dc.subjectReceptoren_US
dc.subjectRaten_US
dc.titleThe Effects of Long-term Growth Hormone Treatment on Ocular Findingsen_US
dc.typeArticleen_US

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