Correlation of F-18-fluorodeoxyglucose uptake with histopathological prognostic factors in breast carcinoma

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dc.contributor.authorEkmekçioğlu, Özgül
dc.contributor.authorAliyev, Anar
dc.contributor.authorAksoy, Sabire Yılmaz
dc.contributor.authorArslan, Esra
dc.contributor.authorDöner, Zübeyde Rana Kaya
dc.contributor.authorKocael, Pınar
dc.contributor.authorSönmezoğlu, Kerim
dc.date.accessioned2020-04-30T22:41:49Z
dc.date.available2020-04-30T22:41:49Z
dc.date.issued2013
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionSonmezoglu, Kerim/0000-0003-1215-5184en_US
dc.descriptionWOS: 000325095700003en_US
dc.descriptionPubMed: 24025919en_US
dc.description.abstractObjectiveThis study investigated the prognostic value of [F-18]-fluorodeoxyglucose (F-18-FDG) uptake in breast carcinomas by comparing F-18-FDG PET/computed tomography (CT) images with histopathological and immunohistochemical prognostic factors.MethodsThis study included 136 women and four men with positive biopsy breast carcinomas who underwent F-18-FDG PET/CT imaging for initial staging. Maximum standardized uptake values (SUVmax) and tumour-to-background SUVmax ratios were calculated and compared with histopathological and immunohistochemical tumour characteristics, patient properties and axillary lymph node involvement. Calculations of SUVmax for men were performed separately.ResultsFor the tumours in women, the mean SUVmax was 10.066.91 and the median SUVmax was 9.05 (0.7-35.0). Primary tumour F-18-FDG uptake and tumour-to-background SUVmax ratios were correlated with tumour size (P<0.001), histological type (P<0.001), histological grade (P=0.004), pleomorphism (P=0.010), mitosis count (P<0.001), lymphatic invasion (P=0.009), necrosis (P=0.005), oestrogen negativity (P=0.004), high Ki-67 level (P<0.001), axillary lymph node involvement (P<0.001) and triple negativity (P=0.002). High Ki-67 level (odds ratio=16; 95% confidence interval=1.6-160; P=0.016) and tumour size (odds ratio=4; 95% confidence interval=1.5-11; P=0.007) were determining factors for high F-18-FDG uptake values. Other clinicopathological and immunohistopathological parameters including progesterone receptor (P=0.211), CerbB2 overexpression (P=0.170), perineural invasion (P=0.053), intratumoural calcification (P=0.438), desmoplasia (P=0.112), tubular formation (P=0.768) and age (P=0.675) were not significantly correlated with F-18-FDG uptake. No significant relationship was observed between the tumour/contralateral breast SUVmax ratio and mitotic count, oestrogen receptor status or triple negativity.Conclusion(18)F-FDG uptake may serve as a prognostic indicator for biological behaviour in breast tumours. (C) 2013 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.en_US
dc.identifier.doi10.1097/MNM.0b013e3283658369en_US
dc.identifier.endpage1067en_US
dc.identifier.issn0143-3636
dc.identifier.issn1473-5628
dc.identifier.issue11en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1055en_US
dc.identifier.urihttps://doi.org/10.1097/MNM.0b013e3283658369
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3254
dc.identifier.volume34en_US
dc.identifier.wosWOS:000325095700003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofNuclear Medicine Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbreast canceren_US
dc.subjectF-18-fluorodeoxyglucoseen_US
dc.subjectpositron emission tomographyen_US
dc.subjectcomputed tomographyen_US
dc.subjectprognostic factorsen_US
dc.titleCorrelation of F-18-fluorodeoxyglucose uptake with histopathological prognostic factors in breast carcinomaen_US
dc.typeArticleen_US

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