Preliminary Characterization of a Polycaprolactone-SurgihoneyRO Electrospun Mesh for Skin Tissue Engineering

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dc.authoridAslan, Enes/0000-0002-1849-2715
dc.authoridYupanqui Mieles, Joel/0000-0002-2256-2480
dc.authoridBartolo, Paulo/0000-0003-3683-726X
dc.authoriddiver, carl/0000-0002-8743-1182
dc.authorwosidAslan, Enes/AAX-8039-2021
dc.authorwosidBartolo, Paulo/F-2421-2013
dc.contributor.authorAslan, Enes
dc.contributor.authorVyas, Cian
dc.contributor.authorYupanqui Mieles, Joel
dc.contributor.authorHumphreys, Gavin
dc.contributor.authorDiver, Carl
dc.contributor.authorBartolo, Paulo
dc.date.accessioned2023-07-26T11:51:12Z
dc.date.available2023-07-26T11:51:12Z
dc.date.issued2022
dc.departmentDÜ, Gümüşova Meslek Yüksekokulu, Makine ve Metal Teknolojileri Bölümüen_US
dc.description.abstractSkin is a hierarchical and multi-cellular organ exposed to the external environment with a key protective and regulatory role. Wounds caused by disease and trauma can lead to a loss of function, which can be debilitating and even cause death. Accelerating the natural skin healing process and minimizing the risk of infection is a clinical challenge. Electrospinning is a key technology in the development of wound dressings and skin substitutes as it enables extracellular matrix-mimicking fibrous structures and delivery of bioactive materials. Honey is a promising biomaterial for use in skin tissue engineering applications and has antimicrobial properties and potential tissue regenerative properties. This preliminary study investigates a solution electrospun composite nanofibrous mesh based on polycaprolactone and a medical grade honey, SurgihoneyRO. The processing conditions were optimized and assessed by scanning electron microscopy to fabricate meshes with uniform fiber diameters and minimal presence of beads. The chemistry of the composite meshes was examined using Fourier transform infrared spectroscopy and X-ray photon spectroscopy showing incorporation of honey into the polymer matrix. Meshes incorporating honey had lower mechanical properties due to lower polymer content but were more hydrophilic, resulting in an increase in swelling and an accelerated degradation profile. The biocompatibility of the meshes was assessed using human dermal fibroblasts and adipose-derived stem cells, which showed comparable or higher cell metabolic activity and viability for SurgihoneyRO-containing meshes compared to polycaprolactone only meshes. The meshes showed no antibacterial properties in a disk diffusion test due to a lack of hydrogen peroxide production and release. The developed polycaprolactone-honey nanofibrous meshes have potential for use in skin applications.en_US
dc.identifier.doi10.3390/ma15010089
dc.identifier.issn1996-1944
dc.identifier.issue1en_US
dc.identifier.pmid35009233en_US
dc.identifier.scopus2-s2.0-85121711695en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.3390/ma15010089
dc.identifier.urihttps://hdl.handle.net/20.500.12684/12515
dc.identifier.volume15en_US
dc.identifier.wosWOS:000752645200001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorAslan, Enes
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofMaterialsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectElectrospinning; Honey; Polycaprolactone; Skinen_US
dc.subjectX-Ray-Diffraction; Extracellular-Matrix; Nanofibrous Membrane; In-Vivo; Oxygen; Honey; Release; Cellsen_US
dc.titlePreliminary Characterization of a Polycaprolactone-SurgihoneyRO Electrospun Mesh for Skin Tissue Engineeringen_US
dc.typeArticleen_US

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