The importance of serial measurements of cytokine levels for the evaluation of their role in pathogenesis in Familial Mediterraean Fever

dc.contributor.authorAkcan, Yusuf
dc.contributor.authorBayraktar, Yusuf
dc.contributor.authorArslan, Serap
dc.contributor.authorVan Thiel, David H.
dc.contributor.authorZerrin, B.C.K.
dc.contributor.authorYıldız, Orhan
dc.date.accessioned2020-04-30T23:33:49Z
dc.date.available2020-04-30T23:33:49Z
dc.date.issued2003
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000184806200005en_US
dc.descriptionPubMed: 12911867en_US
dc.description.abstractFamilial Mediterranean fever (FMF) is an autosomal recessive disorder characterized by recurrent fever of unknown origin, renal amyloidosis, peritonitis, pleuritis and/or synovitis. There have been many studies to elucidate the etiopathogenesis of FMF. IL-6 is a cytokine that can induce the formation of serum amyloid A and C-reactive protein, both of which are important in development of amyloidosis. IL-6 was determined to be strongly associated in the etiopathogenesis of periodic fever in Chinese-pei dogs. The dogs with this syndrome experience periodic fever, arthritis, renal amyloidosis, a clinical picture very alike of human FMF. Here, we aimed to study mainly whether IL-6 had a similar etiopathogenetic role in human FMF as in Chinese-pei dogs syndrome. The median IL-6 blood levels were found to be higher in patients with acute (n=8) FMF attack (1.85 U/ml) compared to those (n=33) with asymptomatic ones (1.0 U/ml) (p=0.16). There are mainly two results: first; the study should be designed with a larger sample size of patients with acute attack in order to alleviate underestimation of significance, second; sampling time may give various results because of dynamic changes of cytokine levels during acute attack period.en_US
dc.identifier.endpage306en_US
dc.identifier.issn0949-2321
dc.identifier.issue7en_US
dc.identifier.startpage304en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5050
dc.identifier.volume8en_US
dc.identifier.wosWOS:000184806200005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherI Holzapfel Verlag Gmbhen_US
dc.relation.ispartofEuropean Journal Of Medical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFamilial Mediterranean Feveren_US
dc.subjectIL-6en_US
dc.subjectrenal amyloidosisen_US
dc.subjectperitonitisen_US
dc.subjectpleuritisen_US
dc.subjectsynovitisen_US
dc.subjectChinese-pei dogs syndromeen_US
dc.titleThe importance of serial measurements of cytokine levels for the evaluation of their role in pathogenesis in Familial Mediterraean Feveren_US
dc.typeArticleen_US

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