The importance of serial measurements of cytokine levels for the evaluation of their role in pathogenesis in Familial Mediterraean Fever
dc.contributor.author | Akcan, Yusuf | |
dc.contributor.author | Bayraktar, Yusuf | |
dc.contributor.author | Arslan, Serap | |
dc.contributor.author | Van Thiel, David H. | |
dc.contributor.author | Zerrin, B.C.K. | |
dc.contributor.author | Yıldız, Orhan | |
dc.date.accessioned | 2020-04-30T23:33:49Z | |
dc.date.available | 2020-04-30T23:33:49Z | |
dc.date.issued | 2003 | |
dc.department | DÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü | en_US |
dc.description | WOS: 000184806200005 | en_US |
dc.description | PubMed: 12911867 | en_US |
dc.description.abstract | Familial Mediterranean fever (FMF) is an autosomal recessive disorder characterized by recurrent fever of unknown origin, renal amyloidosis, peritonitis, pleuritis and/or synovitis. There have been many studies to elucidate the etiopathogenesis of FMF. IL-6 is a cytokine that can induce the formation of serum amyloid A and C-reactive protein, both of which are important in development of amyloidosis. IL-6 was determined to be strongly associated in the etiopathogenesis of periodic fever in Chinese-pei dogs. The dogs with this syndrome experience periodic fever, arthritis, renal amyloidosis, a clinical picture very alike of human FMF. Here, we aimed to study mainly whether IL-6 had a similar etiopathogenetic role in human FMF as in Chinese-pei dogs syndrome. The median IL-6 blood levels were found to be higher in patients with acute (n=8) FMF attack (1.85 U/ml) compared to those (n=33) with asymptomatic ones (1.0 U/ml) (p=0.16). There are mainly two results: first; the study should be designed with a larger sample size of patients with acute attack in order to alleviate underestimation of significance, second; sampling time may give various results because of dynamic changes of cytokine levels during acute attack period. | en_US |
dc.identifier.endpage | 306 | en_US |
dc.identifier.issn | 0949-2321 | |
dc.identifier.issue | 7 | en_US |
dc.identifier.startpage | 304 | en_US |
dc.identifier.uri | https://hdl.handle.net/20.500.12684/5050 | |
dc.identifier.volume | 8 | en_US |
dc.identifier.wos | WOS:000184806200005 | en_US |
dc.identifier.wosquality | Q3 | en_US |
dc.indekslendigikaynak | Web of Science | en_US |
dc.indekslendigikaynak | PubMed | en_US |
dc.language.iso | en | en_US |
dc.publisher | I Holzapfel Verlag Gmbh | en_US |
dc.relation.ispartof | European Journal Of Medical Research | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Familial Mediterranean Fever | en_US |
dc.subject | IL-6 | en_US |
dc.subject | renal amyloidosis | en_US |
dc.subject | peritonitis | en_US |
dc.subject | pleuritis | en_US |
dc.subject | synovitis | en_US |
dc.subject | Chinese-pei dogs syndrome | en_US |
dc.title | The importance of serial measurements of cytokine levels for the evaluation of their role in pathogenesis in Familial Mediterraean Fever | en_US |
dc.type | Article | en_US |