Prevalence of sarcopenia in heart failure with mildly reduced ejection fraction and its impact on clinical outcomes

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dc.authoridKILIC, RAIF/0000-0002-8338-4948
dc.authoridDemirci, Murat/0000-0002-8835-9557
dc.authoridGUZEL, TUNCAY/0000-0001-8470-1928
dc.authoridKaya, Ahmet Ferhat/0000-0003-0544-0657
dc.authoridArslan, Bayram/0000-0003-2984-9094
dc.authoridKARAHAN, Mehmet Zulkif/0000-0001-8145-9574;
dc.contributor.authorKilic, Raif
dc.contributor.authorGuzel, Tuncay
dc.contributor.authorAktan, Adem
dc.contributor.authorGuzel, Hamdullah
dc.contributor.authorKaya, Ahmet Ferhat
dc.contributor.authorArslan, Bayram
dc.contributor.authorDemirci, Murat
dc.date.accessioned2025-10-11T20:48:23Z
dc.date.available2025-10-11T20:48:23Z
dc.date.issued2024
dc.departmentDüzce Üniversitesien_US
dc.description.abstractBackground: Sarcopenia is a progressive age-related skeletal muscle disease associated with adverse outcomes in those with cardiovascular disease. In this study, the prevalence of sarcopenia and its effect on clinical outcomes in heart failure with mildly reduced ejection fraction (HFmrEF) patients were examined. Methods: A total of 722 patients from three centres who applied to the outpatient clinic with the diagnosis of HFmrEF between 01 January 2020 and 01 June 2021 were included in the study retrospectively. Sarcopenia was diagnosed with a screening test using age, grip srength and calf circumference. At least two-year follow-up results were reviewed from the date the patients were included in the study. Results: Of the 722 HFmrEF patients, 169 (23.4%) were sarcopenic. During the follow-up of sarcopenic patients, a higher rate of hospitalisation and two-year mortality was detected compared to the non-sarcopenic group (49.7% vs 33.3%, p < .001 and 23.7% vs 13.2%, p = .001, respectively). Additionally, atrial fibrillation (AF), chronic obstructive pulmonary disease (COPD), chronic renal failure (CRF) and smoking were detected at higher rates in sarcopenic patients. In subgroup analysis, AF was found to be significantly higher in overweight/obese sarcopenia patients compared to other groups. According to Receiver operating characteristic (ROC) analysis, the sarcopenia score cut-off of 73.61 predicted mortality with 65% sensitivity and 63% specificity, and the cut-off level of 71.10 predicted hospitalisation with 68% sensitivity and 69% specificity. Conclusion: In HFmrEF patients, sarcopenia is associated with adverse events and is an important prognostic marker.en_US
dc.identifier.doi10.1080/00015385.2024.2410604
dc.identifier.endpage923en_US
dc.identifier.issn0001-5385
dc.identifier.issn1784-973X
dc.identifier.issue8en_US
dc.identifier.pmid39377136en_US
dc.identifier.scopus2-s2.0-85205759501en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage915en_US
dc.identifier.urihttps://doi.org/10.1080/00015385.2024.2410604
dc.identifier.urihttps://hdl.handle.net/20.500.12684/21895
dc.identifier.volume79en_US
dc.identifier.wosWOS:001331202800001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofActa Cardiologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250911
dc.subjectHeart failure with mildly reduced ejection fractionen_US
dc.subjectsarcopeniaen_US
dc.subjectgrip strengthen_US
dc.subjectcalf circumferenceen_US
dc.subjectatrial fibrillationen_US
dc.subjectmortalityen_US
dc.titlePrevalence of sarcopenia in heart failure with mildly reduced ejection fraction and its impact on clinical outcomesen_US
dc.typeArticleen_US

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