Efficacy of Short-Term High-Dose Atorvastatin for Prevention of Contrast-Induced Nephropathy in Patients Undergoing Coronary Angiography

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dc.contributor.authorÖzhan, Hakan
dc.contributor.authorErden, İsmail
dc.contributor.authorOrdu, Serkan
dc.contributor.authorAydın, Mesut
dc.contributor.authorÇağlar, Onur
dc.contributor.authorBaşar, Cengiz
dc.contributor.authorAlemdar, Recai
dc.date.accessioned2020-05-01T09:12:08Z
dc.date.available2020-05-01T09:12:08Z
dc.date.issued2010
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000281677000014en_US
dc.descriptionPubMed: 20395226en_US
dc.description.abstractContrast-induced nephropathy (CIN) is associated with increased morbidity, extended hospital stay, and higher costs. We compared an atorvastatin plus N-acetylcysteine (NAC) regimen with NAC alone in patients undergoing coronary angiography. A total of 130 patients (mean age 54 +/- 10; 77 men) undergoing coronary angiography were studied. Seven CIN cases occurred in the NAC group and 2 in the atorvastatin + NAC group; this difference was not significant. Baseline mean creatinine and estimated glomerular filtration rate (eGFR) were similar between the 2 groups, whereas after the procedure there was a significant creatinine decrease and eGFR increase in the atorvastatin + NAC group. Change in creatinine (baseline creatinine-creatinine after the procedure) was also significantly higher in patients taking statin plus NAC. Atorvastatin may be effective in protecting patients undergoing coronary angiography from CIN.en_US
dc.identifier.doi10.1177/0003319710364216en_US
dc.identifier.endpage714en_US
dc.identifier.issn0003-3197
dc.identifier.issn1940-1574
dc.identifier.issue7en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage711en_US
dc.identifier.urihttps://doi.org/10.1177/0003319710364216
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5886
dc.identifier.volume61en_US
dc.identifier.wosWOS:000281677000014en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofAngiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcontrast-induced nephropathyen_US
dc.subjectatorvastatinen_US
dc.subjectN-acetylcysteineen_US
dc.titleEfficacy of Short-Term High-Dose Atorvastatin for Prevention of Contrast-Induced Nephropathy in Patients Undergoing Coronary Angiographyen_US
dc.typeArticleen_US

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