A Retrospective Investigation of Clozapine Treatment in Autistic and Nonautistic Children and Adolescents in an Inpatient Clinic in Turkey

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dc.contributor.authorYalçın, Özhan
dc.contributor.authorKaymak, Gizem
dc.contributor.authorErdoğan, Ayten
dc.contributor.authorTanıdır, Canan
dc.contributor.authorKaraçetin, Gül
dc.contributor.authorKılıçoğlu, Ali Güven
dc.contributor.authorÜneri, Özden Şükran
dc.date.accessioned2020-04-30T22:38:51Z
dc.date.available2020-04-30T22:38:51Z
dc.date.issued2016
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000388118400007en_US
dc.descriptionPubMed: 26771824en_US
dc.description.abstractObjective: The aim of this retrospective study is to examine the clinical outcomes and safety of clozapine in children and adolescents with schizophrenia or other psychotic disorders/autism spectrum disorder (ASD) or affective disorders. Methods: The inpatient and outpatient files of all children and adolescents treated with clozapine over a period of 34 months (from October 2011 to July 2014) were reviewed. Demographic and clinical data were examined to describe clinical and metabolic findings, dosing, and tolerability of clozapine treatment in youth with schizophrenia, other psychotic disorders, ASD, or bipolar disorder. Results: The 37 pediatric patients included 26 patients with schizophrenia or other psychotic disorders, 7 patients with ASD complicated by schizophrenia or other psychotic disorders or affective disorders, and 4 patients with ASD only. In all groups (n = 37) there was a significant reduction (p < 0.001) in Brief Psychiatric Rating Scale (BPRS) points after clozapine treatment during the inpatient period (38.78 +/- 27.75 days). In patients with schizophrenia or other psychotic disorders co-occurring with ASD or not (n = 31), there was a significant improvement in psychotic symptoms according to Positive and Negative Syndrome Scale (PANSS) total scores and subscores (p < 0.001). Of the 26 patients with schizophrenia or other psychotic disorders, 8 (30.8%) showed a positive response (>30% symptom reduction on BPRS). In patients with ASD complicated by schizophrenia or other psychotic disorders or bipolar disorders (n = 7), there was a significant reduction (p = 0.017) in BPRS scores after clozapine treatment. The discontinuation rate for clozapine was 10.8%, and the most frequently observed side effect was hypersalivation (54.1%). Neutropenia associated with clozapine was observed in only one patient (2.7%). Conclusions: Clozapine seems to be effective and safe in children and adolescents with schizophrenia or other psychotic disorders co-occuring with ASD or not. There is a need for further studies for determining the efficacy of clozapine in children and adolescents with bipolar affective disorder or ASD.en_US
dc.identifier.doi10.1089/cap.2015.0020en_US
dc.identifier.endpage821en_US
dc.identifier.issn1044-5463
dc.identifier.issn1557-8992
dc.identifier.issue9en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage815en_US
dc.identifier.urihttps://doi.org/10.1089/cap.2015.0020
dc.identifier.urihttps://hdl.handle.net/20.500.12684/2485
dc.identifier.volume26en_US
dc.identifier.wosWOS:000388118400007en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMary Ann Liebert, Incen_US
dc.relation.ispartofJournal Of Child And Adolescent Psychopharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectclozapineen_US
dc.subjectschizophreniaen_US
dc.subjectearly onset schizophreniaen_US
dc.subjectvery early onset schizophreniaen_US
dc.subjectautismen_US
dc.subjectautism spectrum disordersen_US
dc.titleA Retrospective Investigation of Clozapine Treatment in Autistic and Nonautistic Children and Adolescents in an Inpatient Clinic in Turkeyen_US
dc.typeArticleen_US

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