Effects of perilipin-5 on lipid metabolism and high-sensitivity cardiac troponin I

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dc.authoridHacıoğlu, Ceyhan/0000-0002-0993-6118
dc.contributor.authorEthem, İbrahim
dc.contributor.authorHacıoğlu, Ceyhan
dc.date.accessioned2023-07-26T11:58:18Z
dc.date.available2023-07-26T11:58:18Z
dc.date.issued2022
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalıen_US
dc.description.abstractOBJECTIVE: Heart attack is one of the most common causes of sudden death in adults. Therefore, early detection of heart attack and investigation of potential new biomarkers are of great importance. We investigated whether perilipin-5 is a potential biomarker by examining changes in perilipin-5 serum levels along with high-sensitivity cardiac troponin I during a heart attack. METHODS: The subjects were divided into two groups: (1) control group and (2) patients with heart attack, with 150 people in each group. High -sensitivity cardiac troponin I, perilipin-5, total oxidant status, malondialdehyde, reduced glutathione, and superoxide dismutase levels in serum samples were measured. In addition, perilipin-5 mRNA expressions and protein levels were analyzed. RESULTS: There was no overall statistical difference between the demographic characteristics of the groups. However, high-density lipoprotein, creatine kinase, Creatine kinase myocardial band, aspartate amino transferase, lactate dehydrogenase, and calcium levels were higher in the heart attack group compared to the control group. We found that the high-sensitivity cardiac troponin I and perilipin-5 levels increased in the patients with heart attack (p<0.0001) compared to control. Although there was an insignificant increase in malondialdehyde levels in the heart attack group (p>0.05), there was a 35.9% increase in total oxidant status levels and a 33.5 and 24.1% decrease in glutathione and superoxide dismutase levels, respectively (p<0.01), compared to control. Perilipin-5 mRNA and protein levels in heart attack patients increased by 48.2 and 23.6%, respectively, compared to the control group (p<0.01). CONCLUSION: Our results showed that perilipin-5 together with high-sensitivity cardiac troponin I could be a promising biomarker in heart attack.en_US
dc.identifier.doi10.1590/1806-9282.20211377
dc.identifier.endpage1016en_US
dc.identifier.issn0104-4230
dc.identifier.issn1806-9282
dc.identifier.issue8en_US
dc.identifier.pmid36134829en_US
dc.identifier.scopus2-s2.0-85138281522en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1011en_US
dc.identifier.urihttps://doi.org/10.1590/1806-9282.20211377
dc.identifier.urihttps://hdl.handle.net/20.500.12684/13454
dc.identifier.volume68en_US
dc.identifier.wosWOS:000865466400010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthor[Ethem, İbrahim
dc.institutionauthorHacıoğlu, Ceyhan
dc.language.isoenen_US
dc.publisherAssoc Medica Brasileiraen_US
dc.relation.ispartofRevista Da Associacao Medica Brasileiraen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectPerilipin-5; Troponin; Heart Disease; Oxidative Stress; Lipid Peroxidationen_US
dc.titleEffects of perilipin-5 on lipid metabolism and high-sensitivity cardiac troponin Ien_US
dc.typeArticleen_US

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