The relationship between Vitamin D deficiency and polycystic ovary syndrome

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dc.authoridOnmez, Attila/0000-0002-7188-7388
dc.contributor.authorGokosmanoglu, Feyzi
dc.contributor.authorOnmez, Attila
dc.contributor.authorErgenc, Hasan
dc.date.accessioned2021-12-01T18:49:58Z
dc.date.available2021-12-01T18:49:58Z
dc.date.issued2020
dc.department[Belirlenecek]en_US
dc.description.abstractBackground: Vitamin D deficiency is frequently seen in patients with polycystic ovary syndrome (PCOS) and has been shown to exhibit multiple effects on the disease process. The purpose of this study was to investigate the role of vitamin D deficiency in complex PCOS pathophysiological pathways. Methods: Two hundred sixty-seven patients with PCOS were divided into two groups Group 1 with 25(OH)D3 deficiency, and Group 2 with normal 25(OH)D3. Biochemical and hormonal parameters (androgen hormones, gonadotropins, and thyroid function tests) were compared between the two groups. Results: Eighty-six percent of the patients (n=231) were in Group 1 and 14% (n=36) in Group 2. Statistically significantly higher concentrations of serum testosterone, dehydroepiandrosterone-sulfate and LH were determined in Group 1 (p<0.05). 25(OH)D3 concentrations were negatively correlated with body mass index (r=-0.459), serum testosterone (r =-0.374) and dehydroepiandrosterone-sulfate levels (r=-0.418); (all; p< 0.05). Conclusion: The study findings show that low 25(OH)D3 levels are associated with high androgen levels in women with PCOS. Vitamin D deficiency should be considered as an additional risk factor in the development of PCOS. We think that providing vitamin D supplementation for women from identified deficiency areas can reduce the risk of PCOS development.en_US
dc.identifier.doi10.4314/ahs.v20i4.45
dc.identifier.endpage1886en_US
dc.identifier.issn1680-6905
dc.identifier.issn1729-0503
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85098057003en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1880en_US
dc.identifier.urihttps://doi.org/10.4314/ahs.v20i4.45
dc.identifier.urihttps://hdl.handle.net/20.500.12684/10807
dc.identifier.volume20en_US
dc.identifier.wosWOS:000677466200013en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMakerere Univ, Fac Meden_US
dc.relation.ispartofAfrican Health Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPolycystic ovarian syndromeen_US
dc.subjectvitamin D deficiencyen_US
dc.subjectandrogen hormonesen_US
dc.subjecttestosteroneen_US
dc.subjectInsulin-Resistanceen_US
dc.subjectCardiovascular-Diseaseen_US
dc.subjectMetabolic Syndromeen_US
dc.subjectD Supplementationen_US
dc.subjectSyndrome Pcosen_US
dc.subjectWomenen_US
dc.subjectAssociationen_US
dc.subjectRisken_US
dc.subjectSensitivityen_US
dc.subjectHormoneen_US
dc.titleThe relationship between Vitamin D deficiency and polycystic ovary syndromeen_US
dc.typeArticleen_US

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