Argyrophilic Nucleolar Organizer Regions as New Biomarkers in ST-Elevation Myocardial Infarction

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dc.authoridDamar, İbrahim Halil/0000-0001-6420-0122
dc.authorwosidEr, Recep/HFZ-9751-2022
dc.contributor.authorDamar, İbrahim Halil
dc.contributor.authorEröz, Recep
dc.date.accessioned2023-07-26T11:58:10Z
dc.date.available2023-07-26T11:58:10Z
dc.date.issued2022
dc.departmentRektörlük, Rektörlüğe Bağlı Birimler, Düzce Üniversitesi Dergilerien_US
dc.description.abstract(1) Background: ST-elevation myocardial infarction (STEMI) is an inflammatory disease in which neutrophils, macrophages, and lymphocytes accumulate in the ischemic myocardium and have important functions. Nucleolar-organizing regions (NORs) are the site of the ribosomal genes composed of ribosomal DNA and proteins. We aimed to evaluate AgNOR proteins, which have never been studied in patients with STEMI in the literature. (2) Methods: A total of 140 participants (75 with STEMI and 65 volunteers without any diagnosis of acute coronary syndrome) were included in this study. Echocardiography was carried out, and mean AgNOR number and total AgNOR area/total nuclear area (TAA/TNA) were evaluated for all individuals. (3) Results: The mean AgNOR number and TAA/TNA ratio were significantly higher in the STEMI group than the control (p < 0.001). Statistically significant relations between both TAA/TNA ratio and mean AgNOR number and interventricular septal thickness, fasting blood sugar, creatinine, HDL, hemoglobin (g/dL), WBC (mu L/mL), monocytes, neutrophils, and neutrophil/lymphocyte ratio were detected (p < 0.05). Moreover, a statistically significant relation between LDL (mg/dL) and mean AgNOR number (p = 0.005) was detected. (4) Conclusion: Both AgNOR protein amounts increase depending on the hypoxia that occurs in STEMI. The AgNOR proteins may thus be promising markers in STEMI.en_US
dc.identifier.doi10.3390/jcdd9020058
dc.identifier.issn2308-3425
dc.identifier.issue2en_US
dc.identifier.pmid35200711en_US
dc.identifier.scopus2-s2.0-85125049313en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3390/jcdd9020058
dc.identifier.urihttps://hdl.handle.net/20.500.12684/13418
dc.identifier.volume9en_US
dc.identifier.wosWOS:000764087100001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorDamar, İbrahim Halil
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofJournal of Cardiovascular Development and Diseaseen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectAgnor; Hypoxia; Ischemia; Stemien_US
dc.subjectProtein-Synthesis; Inflammation; Cellsen_US
dc.titleArgyrophilic Nucleolar Organizer Regions as New Biomarkers in ST-Elevation Myocardial Infarctionen_US
dc.typeArticleen_US

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