Cerebrospinal fluid and serum levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in patients with severe head injury

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dc.contributor.authorSanus, Galip Zihni
dc.contributor.authorTanrıverdi, Taner
dc.contributor.authorCoşkun, Abdurrahman
dc.contributor.authorHanımoğlu, Hakan
dc.contributor.authorİş, Merih
dc.contributor.authorUzan, Mustafa
dc.date.accessioned2020-04-30T22:40:36Z
dc.date.available2020-04-30T22:40:36Z
dc.date.issued2007
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionCoskun, Abdurrahman/0000-0002-1273-0604; Uzan, Mustafa/0000-0001-7214-380X; Sanus, Galip Zihni/0000-0001-6539-7254en_US
dc.descriptionWOS: 000256795800004en_US
dc.descriptionPubMed: 17978909en_US
dc.description.abstractBACKGROUND The aim of this study is to present time course of insulin like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) levels in both cerebrospinal fluid (CSF) and serum of patients after severe head injury (SHI) and to compare with controls. METHODS Our trauma and control groups included 11 consecutive patients with isolated SHI and 9 patients with hydrocephalus (one with normotensive and eight with hydrocephalus due to aqueduct stenosis), respectively. Both serum and cerebrospinal fluid levels of IGF-1 and IGFBP-3 were measured during post-traumatic days and we compared the levels with controls. RESULTS Patients and controls showed undetectable levels of both IGF-1 and IGFBP-3 in their CSF. When considering serum levels, patients with SHI had always lower levels of both molecules than that of controls. CONCLUSION Administration of IGF-1 during acute, as well as chronic phase of severe head trauma may provide beneficial effects and may decrease both mortality and morbidity in humans with SHI.en_US
dc.identifier.endpage287en_US
dc.identifier.issn1306-696X
dc.identifier.issue4en_US
dc.identifier.startpage281en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3020
dc.identifier.volume13en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Assoc Trauma Emergency Surgeryen_US
dc.relation.ispartofUlusal Travma Ve Acil Cerrahi Dergisi-Turkish Journal Of Trauma & Emergency Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbrain trauma/drug therapyen_US
dc.subjectIGF-1en_US
dc.subjectIGFBP-3en_US
dc.subjectimmunohistochemistry/methodsen_US
dc.subjectneuroprotectionen_US
dc.subjectsevere head injuryen_US
dc.titleCerebrospinal fluid and serum levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in patients with severe head injuryen_US
dc.typeArticleen_US

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