Assessment of Serum Sialic Acid and Oxidative Stress Parameters in Rheumatoid Arthritis Patients Receiving Anti-TNF-alpha and Conventional Therapies

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dc.contributor.authorErer, Burak
dc.contributor.authorYazıcı, Selma
dc.contributor.authorYılmaz, Gülsen
dc.contributor.authorYılmaz, Fatma Meriç
dc.contributor.authorErer, Betül
dc.contributor.authorYüksel, Hatice
dc.date.accessioned2020-04-30T22:39:48Z
dc.date.available2020-04-30T22:39:48Z
dc.date.issued2010
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionYilmaz, Gulsen/0000-0002-9630-3852;en_US
dc.descriptionWOS: 000296178600005en_US
dc.description.abstractObjective: In this study, we aimed to evaluate sialic acid (SA) levels and oxidative stress parameters by measuring nitric oxide metabolites (NOx), thiobarbituric acid-reactive substances (TBARS) and thiol (SH) in rheumatoid arthritis (RA) patients treated with either conventional or anti-tumor necrosis factor-alpha (anti-TNF-alpha) therapy. Materials and Methods: Eighty-six RA patients and 20 healthy controls were enrolled in the study. All RA patients fulfilled the American College of Rheumatology (ACR) criteria for RA. Thirty patients were on anti-TNF-a therapy. The rest of the patients were either treated with two or three disease-modifying anti-rheumatic drugs. Health Assessment Questionnaire (HAQ) score and the Disease Activity Score 28 (DAS28) were calculated in all patients. NOx, TBARS, SA, and SH levels were measured in both patients and controls. Results: The SA levels were statistically higher in RA patients than in controls. We found increased levels of TBARS and NOx and decreased levels of SH in both groups, but these results were statistically insignificant. Spearman correlation analysis revealed positive correlation between serum TBARS levels and both NOx (r=0.322, p=0.001) and SA (r=0.242, p=0.017) levels. Conclusion: Our results confirm the role of SA in the pathogenesis of RA and its correlation with oxidative stress. Further studies on larger numbers of subjects and with longer treatment durations are needed to analyze the long-term effects of RA therapies on serum oxidative stress parameters. Turk J Phys Med Rehab 2010;56:182-5.en_US
dc.identifier.doi10.4274/tftr.56.182en_US
dc.identifier.endpage185en_US
dc.identifier.issn1302-0234
dc.identifier.issue4en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage182en_US
dc.identifier.urihttps://doi.org/10.4274/tftr.56.182
dc.identifier.urihttps://hdl.handle.net/20.500.12684/2830
dc.identifier.volume56en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofTurkiye Fiziksel Tip Ve Rehabilitasyon Dergisi-Turkish Journal Of Physical Medicine And Rehabilitationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnti-TNF-alphaen_US
dc.subjecttreatmenten_US
dc.subjectoxidative stressen_US
dc.subjectrheumatoid arthritisen_US
dc.subjectsialic aciden_US
dc.titleAssessment of Serum Sialic Acid and Oxidative Stress Parameters in Rheumatoid Arthritis Patients Receiving Anti-TNF-alpha and Conventional Therapiesen_US
dc.typeArticleen_US

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