Effects of Drone Brood Homogenate on Wound Healing: An Experimental Study on Rats

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dc.contributor.authorArican, Mehmet
dc.contributor.authorKekecoglu, Meral
dc.contributor.authorTurhan, Yalcin
dc.contributor.authorCaprazli, Tugce
dc.contributor.authorGamsizkan, Mehmet
dc.contributor.authorKaraduman, Zekeriya Okan
dc.date.accessioned2025-10-11T20:48:47Z
dc.date.available2025-10-11T20:48:47Z
dc.date.issued2025
dc.departmentDüzce Üniversitesien_US
dc.description.abstractBackground Wound healing is one of the most interesting topics in orthopaedic surgery, and there are many studies on the factors and mechanisms affecting this process. Objectives To evaluated the macroscopic and histopathological results of drone larvae homogenate (DLH) on wound healing in a full-thickness wound model. Methods Thirty male wistar rats (6-8 weeks, 250 +/- 50 g) were used. A uniform circular full-thickness wound of approximately 18.44 +/- 1.45 (control), 19.02 +/- 1.24 (silverdin), 19.37 +/- 1.28 (DLH) mm2 was excised on the back of each rat. They were divided into control (n: 10), silverdin (n: 10) and DLH (n: 10) groups. DLH, collected from the beehive for 3-7 days in late spring and ready for use after homogenization and lyophilization. Two mL of physiological saline, silver sulfadiazine 1% and DLH were applied to the control, silverdin and DLH groups, respectively, and a thin layer that completely covered the wound, and repeated every 2 days for all groups for 14 days. The condition of the lesions was observed every 2 days and the amount of contraction and granulation tissue formed in the lesion was recorded. The lesioned areas was examined histopathologically. Results There was no statistically significant difference in lymphocyte, fibroblast, scar thickness, polymorphonuclear leukocyte (PMNL), minivascular density (CD34) and transforming growth factor-beta 1 (TGF-beta 1) among the control, silverdin and DLH groups (p = 0.771, 0.434, 0.07, 0.396). The scar density of the DLH group was found to be higher than the control and silverdin groups (p = 0.003). The average wound diameter of the control group (6.87 +/- 0.93 mm2) on the 10th day was found to be higher than the silverdin (4.39 +/- 1.15 mm2) and DLH groups (4.16 +/- 0.55 mm2) (p = 0.0001). Conclusions DLH has a positive effect on wound healing, especially by ensuring early wound contraction and wound scar formation.en_US
dc.description.sponsorshipDuzce University Scientific Research Projects unit for animal care and supply [2019.04.02.969]en_US
dc.description.sponsorshipThis study was supported by Duzce University Scientific Research Projects unit for animal care and supply (Grant 2019.04.02.969).en_US
dc.identifier.doi10.1002/vms3.70260
dc.identifier.issn2053-1095
dc.identifier.issue2en_US
dc.identifier.pmid40062524en_US
dc.identifier.scopus2-s2.0-105000000489en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1002/vms3.70260
dc.identifier.urihttps://hdl.handle.net/20.500.12684/22108
dc.identifier.volume11en_US
dc.identifier.wosWOS:001440436600001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofVeterinary Medicineand Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_WOS_20250911
dc.subjectdrone brooden_US
dc.subjectfull-thicknessen_US
dc.subjecthomogenateen_US
dc.subjectraten_US
dc.subjectwound healingen_US
dc.titleEffects of Drone Brood Homogenate on Wound Healing: An Experimental Study on Ratsen_US
dc.typeArticleen_US

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