Toxin components and toxicological importance of Galerina marginata from Turkey

Basit Öğe Kaydı
dc.authoridkaya, ertugrul/0000-0003-0081-682X
dc.authorwosidkaya, ertugrul/C-1505-2013
dc.authorwosidAkata, Ilgaz/AAH-6004-2020
dc.contributor.authorAkata, Ilgaz
dc.contributor.authorYilmaz, Ismail
dc.contributor.authorKaya, Ertugrul
dc.contributor.authorCoskun, Nuri Cenk
dc.contributor.authorDonmez, Mert
dc.date.accessioned2021-12-01T18:49:49Z
dc.date.available2021-12-01T18:49:49Z
dc.date.issued2020
dc.department[Belirlenecek]en_US
dc.description.abstractAmatoxins, most of which are hepatotoxic, can cause fatal intoxication. While mushrooms in the amatoxin-containing Galerina genus are rare, they can poison humans and animals worldwide. Few studies have profiled the toxicity of Galerina marginata. In addition, many studies indicate that macrofungi can have different characteristics in different regions. In this study, the quantities of toxins present in G. marginata from different provinces in Turkey were analysed using reversed-phase high-performance liquid chromatography with ultraviolet detection (RP-HPLC-UV) and liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS). G. marginata samples were collected from three different regions of Turkey. The taxonomic categorization of mushrooms was based on their micro- and macroscopic characteristics. The presence of toxins alpha-amanitin (AA), beta-amanitin (BA), gamma-amanitin (GA), phalloidin (PHD) and phallacidin (PHC) quantities were measured using RP-HPLC-UV and then were confirmed using LC-ESI-MS/MS. BA levels were higher than AA levels in G. marginata mushrooms collected from all three regions. Moreover, the levels of GA were below the detection limit and no phallotoxins were detected. This is the first study to identify and test the toxicity of G. marginata collected from three different regions of Turkey using RP-HPLC-UV. This is also the first study to confirm the UV absorption of amatoxins in G. marginata using LC-ESI-MS/MS, which is a far more sensitive process. More studies evaluating the toxicity of G. marginata in other geographic regions of the world are needed.en_US
dc.identifier.doi10.1016/j.toxicon.2020.08.017
dc.identifier.endpage34en_US
dc.identifier.issn0041-0101
dc.identifier.scopus2-s2.0-85090029396en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage29en_US
dc.identifier.urihttps://doi.org/10.1016/j.toxicon.2020.08.017
dc.identifier.urihttps://hdl.handle.net/20.500.12684/10782
dc.identifier.volume187en_US
dc.identifier.wosWOS:000582386000005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofToxiconen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAmanitinen_US
dc.subjectPhallotoxinen_US
dc.subjectGalerina marginataen_US
dc.subjectRP-HPLCen_US
dc.subjectLC-ESI-MS/MSen_US
dc.subjectAmanita-Phalloidesen_US
dc.subjectFermentative Productionen_US
dc.subjectAmatoxinsen_US
dc.subjectPhallotoxinsen_US
dc.subjectTissuesen_US
dc.titleToxin components and toxicological importance of Galerina marginata from Turkeyen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
10782.pdf
Boyut:
2.08 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu