Mean platelet volume in patients with non-alcoholic fatty liver disease

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dc.contributor.authorÖzhan, Hakan
dc.contributor.authorAydın, Mesut
dc.contributor.authorYazıcı, Mehmet
dc.contributor.authorYazgan, Ömer
dc.contributor.authorBaşar, Cengiz
dc.contributor.authorGüngör, Adem
dc.contributor.authorÖnder, Elif
dc.date.accessioned2020-04-30T23:19:07Z
dc.date.available2020-04-30T23:19:07Z
dc.date.issued2010
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000275057800004en_US
dc.descriptionPubMed: 19947902en_US
dc.description.abstractMean platelet volume (MPV) is an indictor of platelet activation. Platelet activation and aggregation are central processes in the pathophysiology of coronary heart disease. Non-alcoholic fatty liver disease (NAFLD) is present up to one-third of the general population and the majority of patients with cardio-metabolic risk factors such as abdominal obesity, type 2 diabetes and other components of the metabolic syndrome (MS). The aim of the current study was to investigate the MPV in patients who had NAFLD. MPV values of the patients with NAFLD and of the patients without fatty liver disease were compared. NAFLD patients had significantly higher body mass index compared to the control cases Among biochemical variables, fasting plasma glucose and triglyceride were significantly higher in the NAFLD group. NAFLD cases also had lower platelet count and higher MPV (10 43 +/- 1.14 vs 9 09 +/- 1.25; p < 0 00 1, respectively) MPV was positively correlated with AST (r 0.186, p<0 042), ALT level (r: 0 279; p 0 002) and the presence of NAFLD (0 492, p<0 001) but negatively correlated with platelet number (r. -0 26; p 0 004) and creatinine (r: -0.255, p 0 005). In logistic regression analysis (age, gender, NAFLD, body mass index, high-density lipid (HDL) cholesterol, systolic and diastolic blood pressure, triglyceride and fasting plasma glucose were used as covariates) only NAFLD was found to be the independent predictor of MPV (Odds Ratio (OR) 21.98) [95% confidence interval (CI) 2.404-201 048, p: 0 006]. We have shown for the first time in the literature that, patients with NAFLD have higher MPV. It may have prognostic value in NAFLD patients indicating a possible cardiovascular disease (CVD) risk increase.en_US
dc.identifier.doi10.3109/09537100903391023en_US
dc.identifier.endpage32en_US
dc.identifier.issn0953-7104
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage29en_US
dc.identifier.urihttps://doi.org/10.3109/09537100903391023
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3656
dc.identifier.volume21en_US
dc.identifier.wosWOS:000275057800004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofPlateletsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectmean platelet volumeen_US
dc.subjectnon-alcoholic fatty liver diseaseen_US
dc.titleMean platelet volume in patients with non-alcoholic fatty liver diseaseen_US
dc.typeArticleen_US

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