Gastrointestinal features of pediatric iga vasculitis and their association with renal complications: an observational study

Basit Öğe Kaydı
dc.authoridkilic saglam, Mukaddes/0000-0002-7231-5461;
dc.contributor.authorSaglam, Mukaddes Kilic
dc.contributor.authorYildirim, Sema
dc.contributor.authorErgueven, Mueferet
dc.contributor.authorSungur, Mehmet Ali
dc.date.accessioned2025-10-11T20:48:46Z
dc.date.available2025-10-11T20:48:46Z
dc.date.issued2025
dc.departmentDüzce Üniversitesien_US
dc.description.abstractImmunoglobulin A (IgA) vasculitis is the most common systemic vasculitis in childhood, primarily affecting the skin, gastrointestinal system (GIS), joints, and kidneys. This study aimed to evaluate the clinical and laboratory characteristics of mild and severe GIS involvement in pediatric patients with IgA vasculitis and to investigate its association with renal involvement. A retrospective review was conducted on 794 pediatric patients diagnosed with IgA vasculitis between 1997 and 2024. Demographic data, clinical findings, and laboratory parameters were collected from patient records. GIS involvement was classified as mild (abdominal pain, vomiting, or occult blood in stool) or severe (melena, hematochezia, or intussusception). Renal involvement was defined based on hematuria, proteinuria, hypertension, or renal insufficiency. Among 794 patients, 430 (54.2%) were male, with a mean age at diagnosis of 7.8 +/- 3.3 years. GIS involvement was observed in 422 (53.1%) patients, of whom 333 (78.9%) had mild GIS involvement and 89 (21.1%) had severe GIS involvement. Renal involvement was detected in 171 (21.5%) patients, and was more frequent in those with GIS involvement (26.3% vs. 16.1%, p = 0.001). GIS (55.6% (n = 306) vs. 47.1% (n = 115)) and renal (24.5% (n = 134) vs. 15.2% (n = 37)) involvement were more common in patients aged > 5 years than in patients <= 5 years (p = 0.027, p = 0.004, respectively). GIS involvement was significantly associated with leukocytosis (p < 0.001) and elevated C-reactive protein (CRP) (p = 0.018), but these parameters did not correlate with renal involvement. Patients with positive fecal occult blood tests had a significantly higher risk of renal involvement (p < 0.001). However, there was no significant difference in renal involvement between patients with mild and severe GIS involvement (p = 0.082). Conclusion: GIS involvement, older age (> 5 years), and the presence of occult blood in stool were associated with a higher likelihood of renal involvement in pediatric IgA vasculitis. However, the severity of GIS involvement did not correlate with renal involvement, suggesting that renal pathology may be influenced by independent mechanisms rather than the severity of GIS symptoms.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkiye (TUBIdot;TAK)en_US
dc.description.sponsorshipOpen access funding provided by the Scientific and Technological Research Council of Turkiye (TUB & Idot;TAK).en_US
dc.identifier.doi10.1007/s00431-025-06157-x
dc.identifier.issn0340-6199
dc.identifier.issn1432-1076
dc.identifier.issue5en_US
dc.identifier.pmid40310537en_US
dc.identifier.scopus2-s2.0-105003957282en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1007/s00431-025-06157-x
dc.identifier.urihttps://hdl.handle.net/20.500.12684/22096
dc.identifier.volume184en_US
dc.identifier.wosWOS:001480177500002en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Journal of Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_WOS_20250911
dc.subjectGastrointestinal systemen_US
dc.subjectHenoch-Sch & ouml;nlein Purpuraen_US
dc.subjectIgA Vasculitisen_US
dc.subjectPediatricen_US
dc.subjectRenal involvementen_US
dc.titleGastrointestinal features of pediatric iga vasculitis and their association with renal complications: an observational studyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu