Detection and comparison of cut-off values for total AgNOR area/nuclear area and AgNOR number/nucleus in benign thyroid nodules and normal thyroid tissue

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dc.contributor.authorEröz, Recep
dc.contributor.authorCücer, Nurhan
dc.contributor.authorÜnlühizarcı, Kürşad
dc.contributor.authorÖztürk, Figen
dc.date.accessioned2020-05-01T09:11:19Z
dc.date.available2020-05-01T09:11:19Z
dc.date.issued2013
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000314931500009en_US
dc.descriptionPubMed: 23364912en_US
dc.description.abstractArgyrophilic nucleolar organising region associated proteins (AgNORs) are of interest in a variety of diseases including thyroid disorders. We have investigated the cut-off values for AgNOR count and with a new approach, Total AgNOR area/nuclear area (TNORa/Na) proportions to discriminate thyrocytes obtained from benign thyroid nodules and normal thyroid tissue. Thirty patients whose fine needle aspiration (FNA) materials were compatible with a benign lesion (named as goiter group) and 30 controls (subjects with normal thyroid tissue) were included. In the control group, biopsy material was obtained from histologically normal thyroid gland operated on because FNA material was compatible with papillary thyroid carcinoma (PTC). These samples were stained for AgNOR and 100 nuclei per individual were examined. Both AgNOR values for individual cells and cut-off values were detected for each group. Patients with goiter had significantly (P<0.001) higher AgNOR count (2.1 +/- 0.6%) and TNORa/Na (6.1 +/- 1.5%) than the control groups (1.4 +/- 0.2 and 3.0 +/- 0.4, respectively). The cut-off values were <1.5 for AgNOR count and <3.8 for TNORa/Na in thyrocytes of the controls. This modified method is an easy and reliable method for discriminating various thyroid disorders, including the differentiation of benign thyroid nodules from malignant ones. It also helps to discriminate thyrocytes obtained from benign nodules from normal thyroid tissue, aiding accurate localisation of sampling in FNA material.en_US
dc.identifier.doi10.1002/cbin.10038en_US
dc.identifier.endpage261en_US
dc.identifier.issn1065-6995
dc.identifier.issn1095-8355
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage257en_US
dc.identifier.urihttps://doi.org/10.1002/cbin.10038
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5499
dc.identifier.volume37en_US
dc.identifier.wosWOS:000314931500009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofCell Biology Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAgNORsen_US
dc.subjectgoiteren_US
dc.subjectNORen_US
dc.subjectproteinen_US
dc.subjectrDNAen_US
dc.subjectthyrocyteen_US
dc.titleDetection and comparison of cut-off values for total AgNOR area/nuclear area and AgNOR number/nucleus in benign thyroid nodules and normal thyroid tissueen_US
dc.typeArticleen_US

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