Systemic tranexamic acid promotes bone healing in a rat model of femur fracture

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dc.authoridKaraduman, Zekeriya Okan/0000-0002-6719-3666
dc.authorwosidOrhan, Zafer/ABI-6563-2020
dc.authorwosidKaraduman, Zekeriya Okan/AAD-6650-2020
dc.contributor.authorKaraduman, Zekeriya Okan
dc.contributor.authorArican, Mehmet
dc.contributor.authorTurhan, Yalcin
dc.contributor.authorTurhal, Ozan
dc.contributor.authorOrhan, Zafer
dc.contributor.authorGamsizkan, Mehmet
dc.date.accessioned2021-12-01T18:47:52Z
dc.date.available2021-12-01T18:47:52Z
dc.date.issued2020
dc.department[Belirlenecek]en_US
dc.description.abstractObjectives: This study aims to investigate the effect of tranexamic acid (TXA) on the union of closed femoral fractures using radiological and histological methods in an experimental rat model. Materials and methods: This experimental study was conducted between June 2017 and February 2018. Closed femoral fractures were created in 36 male Wistar albino rats (age: three months [range. 2.5-3.5 months]. weighing 200 grams [range. 180-220 grams]). Half of the animals randomly divided into two groups were administered intravenous single dose of TXA (30 mg/kg). whereas the animals in the control group did not receive any medication. The animals in the two groups were randomly divided into three groups with six animals each and cervical dislocation was performed at days 15, 30, and 45, and radiological and histopathological healing scores were compared. Results: When the mean radiological scores of the TXA and control groups were compared. a statistically significant difference was found in favor of the TXA group at day 15 (p=0.019). but no significant difference was found in the mean scores on days 30 and 45 (p=0.138 and p=0.269. respectively). Histopathological examination also showed a statistically significant difference between the 15-day mean score values in favor of the TXA group (p=0.017). Conclusion: The use of systemic TXA accelerates early bone formation and fracture healing.en_US
dc.description.sponsorshipScientific Research Projects Unit of Duzce University, Duzce, TurkeyDuzce University [2018.4.2.666]en_US
dc.description.sponsorshipThis research was supported by grants from the Scientific Research Projects Unit of Duzce University, Duzce, Turkey (2018.4.2.666).en_US
dc.identifier.doi10.5606/ehc.2020.75430
dc.identifier.endpage439en_US
dc.identifier.issn2687-4784
dc.identifier.issn2687-4792
dc.identifier.issue3en_US
dc.identifier.pmid32962572en_US
dc.identifier.scopus2-s2.0-85089496663en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage432en_US
dc.identifier.urihttps://doi.org/10.5606/ehc.2020.75430
dc.identifier.urihttps://hdl.handle.net/20.500.12684/10397
dc.identifier.volume31en_US
dc.identifier.wosWOS:000573941100005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTurkish Joint Diseases Foundationen_US
dc.relation.ispartofJoint Diseases And Related Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectExperimental rat modelen_US
dc.subjectfracture healingen_US
dc.subjecttranexamic aciden_US
dc.subjectLocal Applicationen_US
dc.subjectBlood-Lossen_US
dc.subjectHemorrhageen_US
dc.subjectAprotininen_US
dc.subjectRepairen_US
dc.titleSystemic tranexamic acid promotes bone healing in a rat model of femur fractureen_US
dc.typeArticleen_US

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