Is Lactate Clearance Useful in Predicting Cardiopulmonary Resuscitation Outcome and 48-Hour Mortality?

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dc.authoridDemir, Mehmet Cihat/0000-0002-0106-3383;
dc.contributor.authorSenguldur, Erdinc
dc.contributor.authorDemir, Mehmet Cihat
dc.contributor.authorSelki, Kudret
dc.date.accessioned2025-10-11T20:47:51Z
dc.date.available2025-10-11T20:47:51Z
dc.date.issued2025
dc.departmentDüzce Üniversitesien_US
dc.description.abstractObjective: To investigate the predictive value of lactate clearance (AL) in witnessed cardiac arrest patients in the emergency department (ED) at two time points: Cardiopulmonary resuscitation (CPR) outcome and 48-hour mortality. Study Design: Observational study. Place and Duration of the Study: Department of Emergency Medicine, Duzce University, Duzce, Turkiye, from July 1 to December 31, 2023. Methodology: Patients aged 18 years and older presenting with cardiac arrest in the ED, whose relatives signed the informed consent form, were included. Out-of-hospital cardiac arrest, trauma-related cardiac arrest, major bleeding, and known malignancy were excluded from the study. All patients who met the criteria were included. All data were recorded prospectively. Receiver operating characteristic (ROC) analysis and risk analysis were performed for lactate clearance (AL) and 20-minut Results: The predictive power of AL at 10 minutes (AL0-10), 20 minutes (AL0-20), and between 10 and 20 minutes (AL10-20) was found to be significantly high for both the likelihood of no-ROSC (return of spontaneous circulation) and 48-hour mortality across all patients. The AUC values for AL at first 10 minutes, 20 minutes, and within 10-20 minutes were 0.991, 0.997, and 0.944, respectively for the no-ROSC group, and 0.942, 0.947, and 0.882, respectively for 48-hour mortality in the ROSC group. ROSC was not achieved in any patient with AL0-20 value of <=-0.15. AL below the calculated thresholds increased the risk of not achieving ROSC and 48-hour mortality by tenfold. Conclusion: AL during CPR is a useful tool to predict the outcome of CPR and 48-hour mortality. The AL0-20 value was evaluated as a valuable parameter that can be used after the 20th minute of CPR when deciding whether to continue or terminate CPR.en_US
dc.identifier.doi10.29271/jcpsp.2025.03.267
dc.identifier.endpage273en_US
dc.identifier.issn1022-386X
dc.identifier.issn1681-7168
dc.identifier.issue3en_US
dc.identifier.pmid40055156en_US
dc.identifier.scopus2-s2.0-86000149819en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage267en_US
dc.identifier.urihttps://doi.org/10.29271/jcpsp.2025.03.267
dc.identifier.urihttps://hdl.handle.net/20.500.12684/21611
dc.identifier.volume35en_US
dc.identifier.wosWOS:001469400600002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherColl Physicians & Surgeons Pakistanen_US
dc.relation.ispartofJcpsp-Journal of the College of Physiciansand Surgeons Pakistanen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_WOS_20250911
dc.subjectEmergency departmenten_US
dc.subjectIn-hospital cardiac arresten_US
dc.subjectLactate clearanceen_US
dc.subjectMortalityen_US
dc.subjectCPR outcomeen_US
dc.titleIs Lactate Clearance Useful in Predicting Cardiopulmonary Resuscitation Outcome and 48-Hour Mortality?en_US
dc.typeArticleen_US

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