ELECTROCHEMICAL OXIDATION OF ATORVASTATIN AND ITS ADSORPTIVE STRIPPING DETERMINATION IN PHARMACEUTICAL DOSAGE FORMS AND BIOLOGICAL FLUIDS

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dc.contributor.authorEskikoy, Dilek
dc.contributor.authorDurmuş, Zehra
dc.contributor.authorKılıç, Esma
dc.date.accessioned2020-05-01T09:12:12Z
dc.date.available2020-05-01T09:12:12Z
dc.date.issued2011
dc.departmentDÜ, Fen-Edebiyat Fakültesi, Kimya Bölümüen_US
dc.descriptionWOS: 000299816100015en_US
dc.description.abstractElectrochemical behavior of atorvastatin (AT) and optimum conditions to its quantitative determination were investigated using voltammetric methods. Some electrochemical parameters such as diffusion coefficient, surface coverage of adsorbed molecules, electron transfer coefficient, standard rate constant and number of electrons were calculated using the results of cyclic voltammetry. A tentative mechanism for the oxidation for AT has been suggested. The oxidation signal of AT molecule was used to develop fully validated, new, rapid, selective and simple square-wave anodic adsorptive stripping voltammetric (AdsSWV) and differential pulse anodic stripping voltammetric (AdsDPV) methods to direct determination of AT in pharmaceutical dosage forms and biological samples. For the AdsDPV and AdsSWV techniques, linear working ranges were found to be 1.0 x 10(-7)-5.0 x 10(-6) and 3.0 x 10(-7)-5.0 x 10-6 mol l(-1), respectively. The detection limits obtained from AdsDPV and AdsSWV were calculated to be 6.55 x 10(-8) and 1.53 x 10(-7) mol l(-1), respectively. The methods were successfully applied to assay the drug in tablets, human blood serum and human urine.en_US
dc.description.sponsorshipAnkara UniversityAnkara University [20050705094]en_US
dc.description.sponsorshipWe gratefully acknowledge the financial support from Ankara University Research Fund (Project No. 20050705094).en_US
dc.identifier.doi10.1135/cccc2011117en_US
dc.identifier.endpage1649en_US
dc.identifier.issn0010-0765
dc.identifier.issue12en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1633en_US
dc.identifier.urihttps://doi.org/10.1135/cccc2011117
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5909
dc.identifier.volume76en_US
dc.identifier.wosWOS:000299816100015en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherInst Organic Chem And Biochemen_US
dc.relation.ispartofCollection Of Czechoslovak Chemical Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAtorvastatinen_US
dc.subjectCholesterol lowering agenten_US
dc.subjectAnodic adsorptive stripping voltammetryen_US
dc.subjectPharmaceuticalsen_US
dc.subjectHuman serumen_US
dc.subjectUrineen_US
dc.subjectGlassy carbon electrodeen_US
dc.titleELECTROCHEMICAL OXIDATION OF ATORVASTATIN AND ITS ADSORPTIVE STRIPPING DETERMINATION IN PHARMACEUTICAL DOSAGE FORMS AND BIOLOGICAL FLUIDSen_US
dc.typeArticleen_US

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