ELECTROCHEMICAL OXIDATION OF ATORVASTATIN AND ITS ADSORPTIVE STRIPPING DETERMINATION IN PHARMACEUTICAL DOSAGE FORMS AND BIOLOGICAL FLUIDS
Yükleniyor...
Dosyalar
Tarih
2011
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Inst Organic Chem And Biochem
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Electrochemical behavior of atorvastatin (AT) and optimum conditions to its quantitative determination were investigated using voltammetric methods. Some electrochemical parameters such as diffusion coefficient, surface coverage of adsorbed molecules, electron transfer coefficient, standard rate constant and number of electrons were calculated using the results of cyclic voltammetry. A tentative mechanism for the oxidation for AT has been suggested. The oxidation signal of AT molecule was used to develop fully validated, new, rapid, selective and simple square-wave anodic adsorptive stripping voltammetric (AdsSWV) and differential pulse anodic stripping voltammetric (AdsDPV) methods to direct determination of AT in pharmaceutical dosage forms and biological samples. For the AdsDPV and AdsSWV techniques, linear working ranges were found to be 1.0 x 10(-7)-5.0 x 10(-6) and 3.0 x 10(-7)-5.0 x 10-6 mol l(-1), respectively. The detection limits obtained from AdsDPV and AdsSWV were calculated to be 6.55 x 10(-8) and 1.53 x 10(-7) mol l(-1), respectively. The methods were successfully applied to assay the drug in tablets, human blood serum and human urine.
Açıklama
WOS: 000299816100015
Anahtar Kelimeler
Atorvastatin, Cholesterol lowering agent, Anodic adsorptive stripping voltammetry, Pharmaceuticals, Human serum, Urine, Glassy carbon electrode
Kaynak
Collection Of Czechoslovak Chemical Communications
WoS Q Değeri
Q3
Scopus Q Değeri
N/A
Cilt
76
Sayı
12
