Expression of nuclear factor-erythroid 2-related factor 2 (Nrf2) in mouse uterus during the peri-implantation period

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dc.authoridAcar, Nuray/0000-0003-2531-0788
dc.contributor.authorSoylu, Hakan
dc.contributor.authorAksu, Kübra
dc.contributor.authorGölal, Ezgi
dc.contributor.authorUstunel, Ismail
dc.contributor.authorIzgut-Uysal, V. Nimet
dc.contributor.authorAcar, Nuray
dc.date.accessioned2023-07-26T11:51:06Z
dc.date.available2023-07-26T11:51:06Z
dc.date.issued2023
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.description.abstractNuclear factor-erythroid 2-related factor- 2 (Nrf2) is a nuclear transcription factor that facilitates transcription of genes for detoxification enzymes and antioxidant proteins. We investigated the distribution and expression of Nrf2 during the peri-implantation period. We detected Nrf2 in uteri of mice during estrus (control) and on days 1, 4, 5, 6 and 8 of pregnancy using immunohistochemistry, quantitative real-time polymerase chain reaction and western blotting. Nrf2 immunostaining was significantly greater on days 1, 5 and 6 of pregnancy compared to controls, and on days 4 and 8 of pregnancy; western blotting results were consistent with immunohistochemical observations. Nrf2 mRNA levels on days 5 and 8 were significantly higher than for control uteri. Increased expression of Nrf2 on days 1, 5 and 6 of pregnancy may be important for uterine receptivity, implantation and decidualization by protecting the developing embryo and uterus from the adverse effects of oxidative stress.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [213S032]en_US
dc.description.sponsorshipThis work was supported by The Scientific and Technological Research Council of Turkey (TUBITAK), grant no. 213S032.en_US
dc.identifier.doi10.1080/10520295.2022.2127156
dc.identifier.endpage139en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue2en_US
dc.identifier.pmid36245360en_US
dc.identifier.scopus2-s2.0-85139947472en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage132en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2022.2127156
dc.identifier.urihttps://hdl.handle.net/20.500.12684/12495
dc.identifier.volume98en_US
dc.identifier.wosWOS:000869140000001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorSoylu, Hakan
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectMouse; Nrf2; Pregnancy; Reactive Oxygen Species; Uterusen_US
dc.subjectOxidative Stress; Implantation; Gene; Rat; Localization; Binding; Embryo; Ovaryen_US
dc.titleExpression of nuclear factor-erythroid 2-related factor 2 (Nrf2) in mouse uterus during the peri-implantation perioden_US
dc.typeArticleen_US

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