Renoprotective Effect of Taxifolin in Paracetamol-Induced Nephrotoxicity: Emerging Evidence from an Animal Model

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dc.authoridTAGHIZADEHGHALEHJOUGHI, Ali/0000-0002-3506-0324
dc.authoridTSATSAKIS, ARISTIDIS/0000-0003-3824-2462
dc.authoridMAMOULAKIS, CHARALAMPOS/0000-0002-8662-1275
dc.authorwosidTSATSAKIS, ARISTIDIS/H-2890-2013
dc.contributor.authorTopal, İsmail
dc.contributor.authorÖzdamar, Mustafa Yaşar
dc.contributor.authorÇataklı, Tülin
dc.contributor.authorMalkoç, İsmail
dc.contributor.authorHacimüftüoğlu, Ahmet
dc.contributor.authorMamoulakis, Charalampos
dc.contributor.authorTsatsakis, Aristidis
dc.date.accessioned2023-07-26T11:51:01Z
dc.date.available2023-07-26T11:51:01Z
dc.date.issued2023
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalıen_US
dc.description.abstractBackground: Taxifolin (TXF) is a flavonoid found abundantly in citrus/onion. Encouraging results on its renoprotective effect have been reported in a limited number of drug-induced nephrotoxicity animal models. The present study aimed to evaluate for the first time the potential renoprotective effects of TXF in a paracetamol (PAR)-induced nephrotoxicity rat model. Methods: Rats were divided into three equal groups (n = 6 animals per group). Group 1 (PAR group, PARG) received PAR diluted in normal saline by gavage (1000 mg/kg). Group 2 (TXF group, TXFG) received TXF diluted in normal saline by gavage (50 mg/kg) one hour after PAR administration. Group 3 (control group, CG) received normal saline. Twenty-four hours after PAR administration, all animals were sacrificed using high-dose anesthesia. Blood samples were collected and kidneys were removed. Results: The serum blood urea nitrogen, creatinine levels and serum malondialdehyde levels were significantly increased in the PARG. The serum glutathione peroxidase, glutathione reductase and total glutathione levels were significantly higher in the TXFG. At the same time, the kidneys of the PARG animals demonstrated tubular epithelium swelling, distension and severe vacuolar degeneration. The kidneys of the TXFG animals showed mildly dilated/congested blood vessels. Conclusions: The TXF renoprotective effects are promising in preventing PAR-induced nephrotoxicity, mainly through antioxidant activity, and warrant further testing in future studies.en_US
dc.identifier.doi10.3390/jcm12030876
dc.identifier.issn2077-0383
dc.identifier.issue3en_US
dc.identifier.pmid36769524en_US
dc.identifier.scopus2-s2.0-85147818149en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3390/jcm12030876
dc.identifier.urihttps://hdl.handle.net/20.500.12684/12477
dc.identifier.volume12en_US
dc.identifier.wosWOS:000930315700001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorHacimüftüoğlu, Ahmet
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofJournal of Clinical Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectAcute Kidney Injury; Kidney; Nephropathy; Paracetamol; Renal Injury; Taxifolin; Toxicityen_US
dc.subjectLipid Peroxides; Acetaminophen; Acid; Glutathione; Proanthocyanidin; Metabolism; Flavonoids; Prevention; Ratsen_US
dc.titleRenoprotective Effect of Taxifolin in Paracetamol-Induced Nephrotoxicity: Emerging Evidence from an Animal Modelen_US
dc.typeArticleen_US

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