Short- and long-term effects of rapamycin on ischemic damage and apoptotic changes in torsion of rat testes

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dc.contributor.authorKabaklioglu, Murat
dc.contributor.authorKaya, Murat
dc.contributor.authorSahin, Ibrahim Ethem
dc.contributor.authorGamsizkan, Mehmet
dc.contributor.authorBahcivan, Atike
dc.contributor.authorEroz, Recep
dc.date.accessioned2021-12-01T18:46:55Z
dc.date.available2021-12-01T18:46:55Z
dc.date.issued2021
dc.department[Belirlenecek]en_US
dc.description.abstractRapamycin has antioxidant defense mechanisms and immune suppressive effects. To detect the short- and long-term effects of rapamycin on ischemic damage and apoptotic changes in torsion of rat testes, mature male albino Wistar rats (n = 48) were included in the study as control, sham, early torsion-detorsion (T/D), early rapamycin treatment, early rapamycin control, late T/D, late rapamycin treatment, and late rapamycin control. The right testis was rotated 720 degrees in a clockwise direction during 4 h in operation groups. Rapamycin was administered orally three times: 30 min before detorsion and 24 and 48 h after detorsion. The animals were killed on the third day in early groups and on the tenth day in late groups after detorsion. Statistically significant differences among all groups were detected for SOD and TBARS, mean seminiferous tubule diameter (MSTD) and Cosentino's histologic score (CHS), caspase 3, bax, average number of apoptotic cells per tubule (ANPCT), and percentage of apoptotic tubule (PAT) values. ANPCT values were 10% lower in the rapamycin treatment groups compared with the untreated T/D groups, and the PAT values were also approximately 1.3 times lower. Although short-term usage of rapamycin may reduce to the tubular injury caused by I/R conversely to apoptosis in the testicular tissue after testicular torsion, rapamycin may have the potential to increase the long-term apoptosis with/without testicular torsion and a subsequent regression in fertility.en_US
dc.description.sponsorshipDUBAP Project [2018.04.02.739]en_US
dc.description.sponsorshipThe study was funded by DUBAP Project Number: 2018.04.02.739.en_US
dc.identifier.doi10.1007/s00210-020-01965-4
dc.identifier.endpage94en_US
dc.identifier.issn0028-1298
dc.identifier.issn1432-1912
dc.identifier.issue1en_US
dc.identifier.pmid32813042en_US
dc.identifier.scopus2-s2.0-85089600269en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage85en_US
dc.identifier.urihttps://doi.org/10.1007/s00210-020-01965-4
dc.identifier.urihttps://hdl.handle.net/20.500.12684/10052
dc.identifier.volume394en_US
dc.identifier.wosWOS:000561013200001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofNaunyn-Schmiedebergs Archives Of Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTesticular torsion and detorsionen_US
dc.subjectRapamycinen_US
dc.subjectApoptosisen_US
dc.subjectIschemic injuryen_US
dc.subjectTesticular Torsionen_US
dc.subjectReperfusion Injuryen_US
dc.subjectOxidative Stressen_US
dc.subjectIschemia/Reperfusionen_US
dc.subjectProtectsen_US
dc.titleShort- and long-term effects of rapamycin on ischemic damage and apoptotic changes in torsion of rat testesen_US
dc.typeArticleen_US

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