Investigation of the effects of pentoxifylline and alpha tocopherol treatment on recovery in rats with Achilles tendon rupture

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dc.authoridUludağ, Veysel/0000-0002-9911-5961en_US
dc.authoridARİCAN, MEHMET/0000-0002-0649-2339en_US
dc.authoridkaraduman, zekeriya okan/0000-0002-6719-3666en_US
dc.authoridKantarcioglu Coskun, Sinem/0000-0002-8133-8665en_US
dc.authoridturhan, yalcin/0000-0002-1440-9566en_US
dc.authoridcelik, mucahit/0009-0004-0187-8525en_US
dc.authoridTOKER, MUSTAFA/0000-0002-0697-9497en_US
dc.authorscopusid58976117100en_US
dc.authorscopusid57209297847en_US
dc.authorscopusid55353048000en_US
dc.authorscopusid23768513300en_US
dc.authorscopusid57212620333en_US
dc.authorscopusid58976388100en_US
dc.authorscopusid58976915900en_US
dc.authorwosidUludağ, Veysel/ABZ-8655-2022en_US
dc.authorwosidARİCAN, MEHMET/AAD-2463-2020en_US
dc.authorwosidkaraduman, zekeriya okan/AAD-6650-2020en_US
dc.contributor.authorToker, Mustafa
dc.contributor.authorKaraduman, Zekeriya Okan
dc.contributor.authorArican, Mehmet
dc.contributor.authorTurhan, Yalcin
dc.contributor.authorCoskun, Sinem Kantarcioglu
dc.contributor.authorDalaslan, Rasit Emin
dc.contributor.authorCelik, Muecahit
dc.date.accessioned2024-08-23T16:07:18Z
dc.date.available2024-08-23T16:07:18Z
dc.date.issued2024en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractAlthough the Achilles tendon is the largest and strongest tendon in the body, healing of the Achilles tendon is the most common injury, and this process is difficult due to poor tendon circulation; moreover, the underlying mechanism has not been fully elucidated. In our study, we aimed to investigate the effects of pentoxifylline and alpha-tocopherol administered separately or in combination on rats with Achilles tendon injury. Forty-eight male Wistar rats weighing 230 +/- 30 g were used in the study. The rats were randomly divided into eight groups of six animals each. Tendons were evaluated histopathologically and biomechanically. According to the statistical analysis, the vascularity density in the pentoxifylline group on day 14 was significantly greater than that in the other groups (p < 0.05). The collagen arrangement in the pentoxifylline and alpha-tocopherol groups on day 14 was found to be firmer and smoother than that in the control group (p < 0.05). The collagen arrangement in the pentoxifylline group on day 28 was greater than that in the other groups (p < 0.05). The biomechanical results were significantly greater in all groups (p < 0.05). Pentoxifylline contributed to tendon healing both through neovascularization in the early period and by improving collagen orientation in the late period, while alpha-tocopherol had a positive effect on collagen orientation in the early period. No beneficial effects were observed when pentoxifylline and alpha-tocopherol were used together. We believe that further research is needed to understand the effects of this combination therapy on tendon healing.en_US
dc.description.sponsorshipDuezce University Scientific Research Projects Unimath;t [2022.04.02.1344]en_US
dc.description.sponsorshipThe experimental animals of our study were provided by Duezce University Scientific Research Projects Un & imath;t with the project numbered (2022.04.02.1344). For this reason, we would like to thank Duzce University.en_US
dc.identifier.doi10.1002/jor.25844
dc.identifier.endpage1915en_US
dc.identifier.issn0736-0266
dc.identifier.issn1554-527X
dc.identifier.issue9en_US
dc.identifier.pmid38564283en_US
dc.identifier.scopus2-s2.0-85189799786en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1907en_US
dc.identifier.urihttps://doi.org/10.1002/jor.25844
dc.identifier.urihttps://hdl.handle.net/20.500.12684/14580
dc.identifier.volume42en_US
dc.identifier.wosWOS:001195327300001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Orthopaedic Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectalpha-tocopherolen_US
dc.subjectinflammationen_US
dc.subjectpentoxifyllineen_US
dc.subjecttendon healingen_US
dc.subjectvasculatureen_US
dc.subjectInjuryen_US
dc.titleInvestigation of the effects of pentoxifylline and alpha tocopherol treatment on recovery in rats with Achilles tendon ruptureen_US
dc.typeArticleen_US

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