Cytokine expression profiles in Autism spectrum disorder: A multi-center study from Turkey

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dc.authoridKILICASLAN, Fethiye/0000-0002-8131-8859
dc.authoridTopal, Zehra/0000-0001-8397-5636
dc.authoridKUTUK, MERYEM/0000-0002-2918-7871
dc.authoridKUTUK, OZGUR/0000-0001-9854-7220
dc.authoridTufan, Evren/0000-0001-5207-6240
dc.authoridKandemir, Hasan/0000-0002-1138-4973
dc.authoridaltintas, ebru/0000-0003-2735-4805
dc.authorwosidKILICASLAN, Fethiye/ABH-8243-2020
dc.authorwosidGOKCEN, CEM/AAA-8919-2021
dc.authorwosidTopal, Zehra/AAE-4882-2019
dc.authorwosidKUTUK, MERYEM/AAI-9626-2021
dc.authorwosidKUTUK, OZGUR/AAH-1671-2019
dc.authorwosidTufan, Evren/C-5074-2015
dc.authorwosidKandemir, Hasan/Z-1954-2018
dc.contributor.authorKutuk, Meryem Ozlem
dc.contributor.authorTufan, Evren
dc.contributor.authorGokcen, Cem
dc.contributor.authorKilicaslan, Fethiye
dc.contributor.authorKaradag, Mehmet
dc.contributor.authorMutluer, Tuba
dc.contributor.authorAcikbas, Ufuk
dc.date.accessioned2021-12-01T18:51:14Z
dc.date.available2021-12-01T18:51:14Z
dc.date.issued2020
dc.department[Belirlenecek]en_US
dc.description.abstractAutism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder characterized by impairments in communication and social interaction as well as restricted interests and repetitive behaviors. The pathogenesis of ASD is not completely understood, but a growing body of research has demonstrated that the immune response may be a contributing factor in the etiology and/or ontogeny of ASD. The aim of this study was to determine the expression levels of IL-1 beta, IL-1 alpha, IL-4, IL-6, IL-17, TNF-alpha and TGF-beta in peripheral blood mononuclear cells of children with ASD and healthy controls in order to determine the contributions of cytokines to ASD. Within the study timeframe, 195 children with ASDs (80.5% male) and 162 controls (73.6% male) were enrolled. Most children with ASD had a comorbid disorder (n = 114, 58.5%), with the most common diagnoses as Intellectual Developmental Disorder (IDD, n = 64, 32.8%) and ADHD (n = 64, 32.8%). The majority of children with ASD had severe autistic symptoms as evaluated via Childhood Autism Rating Scale (CARS, n = 130, 64.6%). The mean CARS score in the ASD sample was 40.8 (S.D. = 7.6). The patients with ASD were found to have significantly higher levels of IL-6 (p < 0.001) and significantly lower levels of IL-17 (p < 0.05, all Bonferroni corrected). Treatment tended to affect IL-4 levels. Lastly, discriminant function analysis (DFA) revealed that a combination of IL-6, IL-17 and IL-1 alpha correctly classified 56.6% of cases. Despite extensive immunological evidence suggesting immune system aberrations, further research is required to clarify the relationship between immune profiles and ASD symptoms.en_US
dc.description.sponsorshipScience Academy BAGEP programen_US
dc.description.sponsorshipOzgur Kutuk acknowledges support from Science Academy BAGEP program.en_US
dc.identifier.doi10.1016/j.cyto.2020.155152
dc.identifier.issn1043-4666
dc.identifier.issn1096-0023
dc.identifier.pmid32563959en_US
dc.identifier.scopus2-s2.0-85086567908en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.cyto.2020.155152
dc.identifier.urihttps://hdl.handle.net/20.500.12684/10983
dc.identifier.volume133en_US
dc.identifier.wosWOS:000554002300029en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAcademic Press Ltd- Elsevier Science Ltden_US
dc.relation.ispartofCytokineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAutism Spectrum Disorderen_US
dc.subjectCytokinesen_US
dc.subjectImmune systemen_US
dc.subjectInflammationen_US
dc.subjectAutoimmune-Diseasesen_US
dc.subjectChildrenen_US
dc.subjectAutoantibodiesen_US
dc.subjectInterleukin-4en_US
dc.subjectAberrationsen_US
dc.subjectReceptorsen_US
dc.subjectRisken_US
dc.subjectCnsen_US
dc.titleCytokine expression profiles in Autism spectrum disorder: A multi-center study from Turkeyen_US
dc.typeArticleen_US

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