A Study of MMP-1 and TGF-β Levels in Lumbar Disc Herniation Patients With and Without Traditional Medical Practices
Küçük Resim Yok
Tarih
2025
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Duzce Univ, Fac Medicine
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Aim: Chronic and recurrent low back pain resulting from lumbar disc disease significantly impacts patients' quality of life and psychological well-being. Patients may seek traditional treatments for pain relief. This study aimed to investigate and evaluate the effect of utilizing or not utilizing traditional medical practices (TMPs) inApatients who have undergone surgery for lumbar disc herniation, by examining samples of the disc and ligamentum flavum. Material and Methods: A total of 46 patients, 28 (60.9%) male and 18 (39.1%) female, who underwent surgical treatment for lumbar disc herniation were included in the study. The patients' data were retrieved retrospectively from the patient registry system. Immunohistochemical staining was performed and evaluated on the disk and ligamentum flavum samples removed during the surgical procedure. Results: Of the 46 patients included in the study, 21 (45.6%) Ahad undergone TMPs, Awhile 25 (54.4%) Ahad not. The levels of MMP-1 and TGF-(3 of patients who underwent TMPs were significantly higher in both flavum (both p<0.001) and disk (p=0.014 and p=0.020, respectively) samples. When analyzing the immunohistochemical staining scores, it was found that MMP-1 staining scores were higher in the flavum (p<0.001) Aand disk (p=0.002) samples of patients who underwent TMPs. Conclusion: The notion that TMPs are suitable methods for all ailments is a significant misconception. This study emphasizes the importance of accurately informing the public about TMPs, given their increasing prevalence in Turkish society. There is a need for further controlled clinical studies to investigate which method can be used for which disease.
Açıklama
Anahtar Kelimeler
Disc Herniation, Traditional Therapy, Mmp-1, Tgf-Beta
Kaynak
Duzce Medical Journal
WoS Q Değeri
Q4
Scopus Q Değeri
N/A
Cilt
27
Sayı
3
