Quercetin- and caffeic acid-functionalized chitosan-capped colloidal silver nanoparticles: one-pot synthesis, characterization, and anticancer and antibacterial activities

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dc.authoridSungur, Mehmet Ali/0000-0001-5380-0819en_US
dc.authoridKARAKUS, HAMZA/0000-0003-2739-7725en_US
dc.authoridKARA OZTABAG, Cansu/0000-0003-2108-2458en_US
dc.authoridAvcioglu, Fatma/0000-0002-6011-7775en_US
dc.authoridYILDIRIM, Muhammet/0000-0003-2933-5296en_US
dc.authorscopusid49763382400en_US
dc.authorscopusid56071562900en_US
dc.authorscopusid56117247300en_US
dc.authorscopusid56364877100en_US
dc.authorscopusid15077376700en_US
dc.authorscopusid57933881500en_US
dc.authorscopusid26322233600en_US
dc.authorwosidSungur, Mehmet Ali/K-9052-2015en_US
dc.contributor.authorKurt, Akif Hakan
dc.contributor.authorOlutas, Elif Berna
dc.contributor.authorAvcioglu, Fatma
dc.contributor.authorKarakus, Hamza
dc.contributor.authorSungur, Mehmet Ali
dc.contributor.authorOztabag, Cansu Kara
dc.contributor.authorYildirim, Muhammet
dc.date.accessioned2024-08-23T16:03:31Z
dc.date.available2024-08-23T16:03:31Z
dc.date.issued2023en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractThe presented study comprises the one-pot synthesis and the characterization of quercetin-and caffeic acid-functionalized chitosan-capped colloidal silver nanoparticles (Ch/Q-and Ch/CA-Ag NPs), and their antibacterial and anticancer activities. The formation of Ch/Q-and Ch/CA-Ag NPs has been confirmed by ultraviolet-visible (UV-vis) spectroscopy, Fourier-transform infrared (FTIR) spectroscopy, and transmission electron microscopy (TEM). The characteristic surface plasmon resonance (SPR) absorption band has been found at 417 and 424 nm for Ch/Q-and Ch/CA-Ag NPs, respectively. The formation of a chitosan shell comprising quercetin and caffeic acid, which surround the colloidal core Ag NPs, was confirmed by UV-vis, and FTIR analyses, and moni-tored by TEM microscopy. The size of nanoparticles has been determined as 11.2 and 10.3 nm for Ch/Q-and Ch/CA-Ag, respec-tively. The anticancer activity of Ch/Q-and Ch/CA-Ag NPs has been evaluated against U-118 MG (human glioblastoma) and ARPE-19 (human retinal pigment epithelium) cells. Both NPs showed anticancer activity, but Ch/Q-Ag NPs seemed to be more effective on cancer cell lines (U-118 MG) in comparison to healthy ones (ARPE-19). Furthermore, the antibacterial activity of Ch/Q-and Ch/CA-Ag NPs against Gram-negative (P. aeruginosa and E. coli) and Gram-positive (S. aureus and S. epidermidis) bacteria was determined, and dose-dependent antibacterial effects were found.en_US
dc.description.sponsorshipBolu Abant Izzet Baysal University, Scientific Research Projects Division (BAP) [2020.08.36.1449]en_US
dc.description.sponsorshipThis study was funded by Bolu Abant Izzet Baysal University, Scientific Research Projects Division (BAP grant no. 2020.08.36.1449) .en_US
dc.identifier.doi10.3762/bjnano.14.31
dc.identifier.endpage376en_US
dc.identifier.issn2190-4286
dc.identifier.pmid36998241en_US
dc.identifier.scopus2-s2.0-85153768953en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage362en_US
dc.identifier.urihttps://doi.org/10.3762/bjnano.14.31
dc.identifier.urihttps://hdl.handle.net/20.500.12684/13790
dc.identifier.volume14en_US
dc.identifier.wosWOS:000956622700001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBeilstein-Instituten_US
dc.relation.ispartofBeilstein Journal of Nanotechnologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAg NPsen_US
dc.subjectanticancer and antibacterial effectsen_US
dc.subjectcaffeic aciden_US
dc.subjectchitosanen_US
dc.subjectone-pot synthesisen_US
dc.subjectquercetinen_US
dc.subjectU-118 MG and ARPE-19 cellsen_US
dc.subjectDressing In-Vitroen_US
dc.subjectAntioxidant Activityen_US
dc.subjectCell-Proliferationen_US
dc.subjectChlorogenic Aciden_US
dc.subjectVivoen_US
dc.subjectBiodistributionen_US
dc.subjectNanocompositesen_US
dc.subjectInflammationen_US
dc.subjectAntitumoren_US
dc.subjectToxicityen_US
dc.titleQuercetin- and caffeic acid-functionalized chitosan-capped colloidal silver nanoparticles: one-pot synthesis, characterization, and anticancer and antibacterial activitiesen_US
dc.typeArticleen_US

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