Predictive values of D-dimer assay, GRACE scores and TIMI scores for adverse outcome in patients with non-ST-segment elevation myocardial infarction

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dc.contributor.authorSatılmışoğlu, Muhammet Hulusi
dc.contributor.authorÖzyılmaz, Sinem Özbay
dc.contributor.authorGül, Mehmet
dc.contributor.authorYıldırım, Hayriye Ak
dc.contributor.authorKayapınar, Osman
dc.contributor.authorGöktürk, Kadir
dc.contributor.authorEksik, Abdurrahman
dc.date.accessioned2020-04-30T23:21:21Z
dc.date.available2020-04-30T23:21:21Z
dc.date.issued2017
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionOzyilmaz, Sinem/0000-0003-4829-8400en_US
dc.descriptionWOS: 000397951200001en_US
dc.descriptionPubMed: 28408834en_US
dc.description.abstractPurpose: To determine the predictive values of D-dimer assay, Global Registry of Acute Coronary Events (GRACE) and Thrombolysis in Myocardial Infarction (TIMI) risk scores for adverse outcome in patients with non-ST-segment elevation myocardial infarction (NSTEMI). Patients and methods: A total of 234 patients (mean age: 57.2 +/- 11.7 years, 75.2% were males) hospitalized with NSTEMI were included. Data on D-dimer assay, GRACE and TIMI risk scores were recorded. Logistic regression analysis was conducted to determine the risk factors predicting increased mortality. Results: Median D-dimer levels were 349.5 (48.0-7,210.0) ng/mL, the average TIMI score was 3.2 +/- 1.2 and the GRACE score was 90.4 +/- 27.6 with high GRACE scores (>118) in 17.5% of patients. The GRACE score was correlated positively with both the D-dimer assay (r= 0.215, P= 0.01) and TIMI scores (r= 0.504, P= 0.000). Multivariate logistic regression analysis revealed that higher creatinine levels (odds ratio = 18.465, 95% confidence interval: 1.059-322.084, P= 0.046) constituted the only significant predictor of increased mortality risk with no predictive values for age, D-dimer assay, ejection fraction, glucose, hemoglobin A1c, sodium, albumin or total cholesterol levels for mortality. Conclusion: Serum creatinine levels constituted the sole independent determinant of mortality risk, with no significant values for D-dimer assay, GRACE or TIMI scores for predicting the risk of mortality in NSTEMI patients.en_US
dc.identifier.doi10.2147/TCRM.S124794en_US
dc.identifier.endpage400en_US
dc.identifier.issn1178-203X
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage393en_US
dc.identifier.urihttps://doi.org/10.2147/TCRM.S124794
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4180
dc.identifier.volume13en_US
dc.identifier.wosWOS:000397951200001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherDove Medical Press Ltden_US
dc.relation.ispartofTherapeutics And Clinical Risk Managementen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectacute coronary syndromeen_US
dc.subjectnon-ST-segment elevation myocardial infarctionen_US
dc.subjectGRACE scoreen_US
dc.subjectD-dimer assayen_US
dc.subjectTIMI scoreen_US
dc.titlePredictive values of D-dimer assay, GRACE scores and TIMI scores for adverse outcome in patients with non-ST-segment elevation myocardial infarctionen_US
dc.typeArticleen_US

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