Investigation of the effects of Toxoplasma gondii on behavioral and molecular mechanism in bradyzoite stage

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dc.authoridAtalar, Mehmet Nuri/0000-0003-2993-2605en_US
dc.authoridAKCAY, GUVEN/0000-0003-3418-8825en_US
dc.authorscopusid57211125848en_US
dc.authorscopusid9842576000en_US
dc.authorscopusid57210943925en_US
dc.authorscopusid57203682358en_US
dc.authorscopusid58583400100en_US
dc.authorscopusid24512412300en_US
dc.authorwosidAtalar, Mehmet Nuri/D-2944-2018en_US
dc.authorwosidTATAR, YAKUP/KIL-1278-2024en_US
dc.authorwosidAKCAY, GUVEN/AAH-6997-2019en_US
dc.contributor.authorAkcay, Guven
dc.contributor.authorBahadir, Anzel
dc.contributor.authorTatar, Yakup
dc.contributor.authorAtalar, Mehmet Nuri
dc.contributor.authorBabur, Cahit
dc.contributor.authorOzkan, Aysegul Taylan
dc.date.accessioned2024-08-23T16:04:56Z
dc.date.available2024-08-23T16:04:56Z
dc.date.issued2024en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractToxoplasma gondii is a single-celled parasite that causes a disease called toxoplasmosis. It can reach the central nervous system, but the mechanism of T. gondii disrupting the functioning of these brain regions occurs in bradyzoite stage of parasite, causing brain damage by forming tissue cysts in brain. In our study, the effects of T. gondii on locomotor activity, anxiety, learning and memory, and norepinephrine (NE), levodopa (L -DOPA), dopamine (DA) and 3,4-D-dihydroxyphenylacetic acid (DOPAC) catecholamines in amygdala, striatum, prefrontal cortex and hippocampus regions of the brain were investigated in bradyzoite stage. Twenty male Albino mice Mus musculus, 4-5 weeks old, weighing 20-25 g, were used. T. gondii inoculated to mice intraperitonealy with 48-50-hour passages of T. gondii RH Ankara strain. For intraperitoneal inoculation of mice 5x104 tachyzoites per mouse. No inoculation was made in control group (n: 20). Locomotor activity behavior in open field test (OFT), anxious behavior in elevated plus maze (EPM), and learning behavior in novel object recognition (NOR) tests were evaluated. NE, L -DOPA, DA and DOPAC were measured by HPLC in brain tissues of amygdala, striatum, prefrontal cortex and hippocampus. A decrease was observed in the locomotor activity, anxiety and learning values of the T. gondii group compared to the control group (p < 0.05). The heighten in NE and L -DOPA levels in amygdala tissue of T. gondii group compared to control group, an elevation in NE, L -DOPA, DA and DOPAC levels in striatum tissue, and an increase in levels of NE in prefrontal cortex tissue were detected in monoamine results. In hippocampus tissue, an increase was observed in DA levels, while a decrease was observed in NE, L -DOPA and DOPAC levels. In our study, it has been shown that T. gondii in bradyzoite stage reduces locomotor activity, causes learning and memory impairment, and has anxiogenic effects.en_US
dc.description.sponsorshipCoordination Unit of Scientific Research Projects of Hitit University [TIP19001.21.007]en_US
dc.description.sponsorshipFunding This work was supported by Coordination Unit of Scientific Research Projects of Hitit University (Project number: TIP19001.21.007) .en_US
dc.identifier.doi10.1016/j.brainres.2024.148762
dc.identifier.issn0006-8993
dc.identifier.issn1872-6240
dc.identifier.pmid38228258en_US
dc.identifier.scopus2-s2.0-85183045396en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.brainres.2024.148762
dc.identifier.urihttps://hdl.handle.net/20.500.12684/14413
dc.identifier.volume1828en_US
dc.identifier.wosWOS:001171054500001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofBrain Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnxietyen_US
dc.subjectBradyzoiteen_US
dc.subjectBrainen_US
dc.subjectDopamineen_US
dc.subjectLearning and Memoryen_US
dc.subjectNorepinephrineen_US
dc.subjectToxoplasma gondiien_US
dc.subjectInfectionen_US
dc.subjectCatecholaminesen_US
dc.subjectSchizophreniaen_US
dc.subjectManipulationen_US
dc.subjectDopamineen_US
dc.subjectStressen_US
dc.subjectMemoryen_US
dc.subjectMiceen_US
dc.titleInvestigation of the effects of Toxoplasma gondii on behavioral and molecular mechanism in bradyzoite stageen_US
dc.typeArticleen_US

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