Predictive value of prehypertension for metabolic syndrome, diabetes, and coronary heart disease among Turks

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dc.contributor.authorOnat, Altan
dc.contributor.authorYazıcı, Mehmet
dc.contributor.authorCan, Günay
dc.contributor.authorKaya, Zekeriya
dc.contributor.authorBulur, Serkan
dc.contributor.authorHergenç, Gülay
dc.date.accessioned2020-04-30T23:21:21Z
dc.date.available2020-04-30T23:21:21Z
dc.date.issued2008
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000258083300014en_US
dc.descriptionPubMed: 18551102en_US
dc.description.abstractBACKGROUND Predictors of prehypertension and the latter's significance in predicting metabolic syndrome (MetS), type 2 diabetes (DM), and incident coronary heart disease (CHD) need further exploration. METHODS Individuals with or without prehypertension (blood pressure (BP) 120-139 systolic or 80-89 mm Hg diastolic) were studied prospectively in a representative sample of Turkish adults. RESULTS Mean age of 1,501 men and 1,533 women was 48 12 years at baseline. Prehypertension, identified in 32.8% of the sample, differed from the normotensive group mainly by age-adjusted obesity measures and C-reactive protein (CRP) and progressed to hypertension at more than twofold annual incidence as normotension did. In logistic regression analysis, adjusted for sex, age, heart rate, and smoking status, prehypertension waspredictive for risk of MetS in both genders (relative risk (RR) 1.55 (95% confidence interval (CI) 1.21; 1.99)) compared with normotensives. However, DM and CHD were significantly predicted by prehypertension only in women (RR 2.06 and 1.98, respectively, for outcomes). Cardiometabolic risks in women were largely independent of obesity. Body mass index (BMI) at baseline predicted significantly subsequent development of new prehypertension in both genders (hazard ratio 1.39 (95% Cl 1.17; 1.65)) and CRP tended to contribute to this risk. CONCLUSIONS Prehypertension, compared with normotension, approximately doubles the risk for DM, MetS, and CHD in women without conferring substantial risk in Turkish men, except toward MetS. Excess cardiometabolic risk of prehypertension in women is independent of obesity. BMI is a determinant of prehypertension.en_US
dc.identifier.doi10.1038/ajh.2008.212en_US
dc.identifier.endpage895en_US
dc.identifier.issn0895-7061
dc.identifier.issn1941-7225
dc.identifier.issue8en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage890en_US
dc.identifier.urihttps://doi.org/10.1038/ajh.2008.212
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4179
dc.identifier.volume21en_US
dc.identifier.wosWOS:000258083300014en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherOxford Univ Pressen_US
dc.relation.ispartofAmerican Journal Of Hypertensionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titlePredictive value of prehypertension for metabolic syndrome, diabetes, and coronary heart disease among Turksen_US
dc.typeArticleen_US

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