In Silico and In Vitro Investigation of Apoptosis-Mediated Antiproliferative Activity of Capsaicin and Alpha-Lipoic Acid Against Prostate Cancer Cells

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dc.contributor.authorMeral, Ogunc
dc.contributor.authorBalkan, Burcu Menekse
dc.contributor.authorBestil, Dilek Nur
dc.contributor.authorSayiner, Serkan
dc.contributor.authorCeylanli, Deniz
dc.contributor.authorUyurca, Sare
dc.contributor.authorSel, Tevhide
dc.date.accessioned2026-07-01T11:39:21Z
dc.date.available2026-07-01T11:39:21Z
dc.date.issued2026
dc.departmentDüzce Üniversitesi
dc.description.abstractNatural products are widely used in the treatment of cancer due to the side effects of chemotherapeutics, and a large number of natural compounds have been reported to have anticancer activities in different types of cancer. The aim of the study was to analyze the antiproliferative and apoptotic effects of capsaicin and alpha-lipoic acid on prostate cancer cells in silico and in vitro. The effects of capsaicin and alpha-lipoic acid on the proliferation of prostate cancer cells were assessed using MTT cell viability assays. Apoptotic protein levels were measured using Western blot analysis. Ligand-protein potential interactions of alpha-lipoic acid and capsaicin with survivin and bax proteins were examined using CB-Dock2 and SwissDock software. Capsaicin and alpha-lipoic acid significantly inhibited the proliferation of both prostate cancer cell lines in a dose- and time-dependent manner. Our data revealed that various concentrations of capsaicin, alpha-lipoic acid and their combinations caused remarkable downregulation of survivin expression on prostate cancer cells. According to the Vina scores, alpha-lipoic acid and capsaicin have the potential to interact strongly with survivin and bax proteins. We suggest that both natural compounds have the potential for treating prostate cancer according to the in vitro and in silico results.
dc.identifier.doi10.3390/cimb48040376
dc.identifier.issn1467-3037
dc.identifier.issn1467-3045
dc.identifier.issue4
dc.identifier.pmid42042036
dc.identifier.scopus2-s2.0-105037071225
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.3390/cimb48040376
dc.identifier.urihttps://hdl.handle.net/20.500.12684/23251
dc.identifier.volume48
dc.identifier.wosWOS:001749422000001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofCurrent Issues in Molecular Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260623
dc.subject[Keyword Not Available]
dc.titleIn Silico and In Vitro Investigation of Apoptosis-Mediated Antiproliferative Activity of Capsaicin and Alpha-Lipoic Acid Against Prostate Cancer Cells
dc.typeArticle

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