Expressions of Notch signalling pathway members during early pregnancy in mice

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dc.authoridSoylu, Hakan/0000-0002-1177-2351en_US
dc.authoridavcı, sema/0000-0002-2860-5592en_US
dc.authoridAcar, Nuray/0000-0003-2531-0788en_US
dc.authorscopusid12806074300en_US
dc.authorscopusid55982152000en_US
dc.authorscopusid57162951400en_US
dc.authorscopusid6602989907en_US
dc.authorwosidSoylu, Hakan/I-8911-2017en_US
dc.authorwosidavcı, sema/I-8850-2017en_US
dc.contributor.authorAcar, Nuray
dc.contributor.authorSoylu, Hakan
dc.contributor.authorAvci, Sema
dc.contributor.authorUstunel, Ismail
dc.date.accessioned2024-08-23T16:07:08Z
dc.date.available2024-08-23T16:07:08Z
dc.date.issued2023en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractAlthough pregnancy is initiated and maintained through highly complex mechanisms, it is essential to understand the events that occur before and during early pregnancy to understand a healthy implantation process. The Notch signal, thought to be involved in this process, is frequently the subject of research with its different aspects. To better understand the role of Notch signaling in the peri-implantation period of the mouse uterus, we investigated the state of expression and localization of Notch 3, Notch 4, Rbp-J, Hes1, Hes7, Hey2, HeyL, and Fbw7 in the uterus and implantation sites in early pregnancy. Balb/C mice were divided into groups D1, D4, D5, D6, and D8. For D5 and D6 groups, implantation sites were identified by intravenous injection of Chicago blue. IHC, WB, and QRT-PCR methods were used. Notch 3 was very strong positive on the 4th day of pregnancy. Notch 4 was highly expressed on days 4, 5, 6, and 8 of pregnancy when P-4 levels were high. Hes 1 level was at the lowest on the 4th day of pregnancy. Hes 7 protein expression gradually increased from D1 to D8 in the uteri and implantation sites. Hey 2 expression was at the highest level on the 1st and 4th days. Hey L expression was on the apical of the glands. Fbxw7 that expression was high on the 1st and 4th days of pregnancy. Notch signaling may play an essential role in regulating endometrial receptivity. In addition, our Hes7 results are new to the literature.en_US
dc.identifier.doi10.1007/s10735-023-10132-x
dc.identifier.endpage312en_US
dc.identifier.issn1567-2379
dc.identifier.issn1567-2387
dc.identifier.issue4en_US
dc.identifier.pmid37344690en_US
dc.identifier.scopus2-s2.0-85162272709en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage297en_US
dc.identifier.urihttps://doi.org/10.1007/s10735-023-10132-x
dc.identifier.urihttps://hdl.handle.net/20.500.12684/14514
dc.identifier.volume54en_US
dc.identifier.wosWOS:001013812800002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Molecular Histologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMouseen_US
dc.subjectPregnancyen_US
dc.subjectUterusen_US
dc.subjectDeciduaen_US
dc.subjectNotch signalingen_US
dc.subjectProtein Membersen_US
dc.subjectDecidualizationen_US
dc.subjectImplantationen_US
dc.subjectReceptorsen_US
dc.subjectDifferentiationen_US
dc.subjectProgesteroneen_US
dc.subjectEndometriumen_US
dc.subjectTrophoblasten_US
dc.subjectLigandsen_US
dc.subjectGenesen_US
dc.titleExpressions of Notch signalling pathway members during early pregnancy in miceen_US
dc.typeArticleen_US

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