Heart rate variability and heart rate recovery in patients with type 1 diabetes mellitus

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dc.contributor.authorTürker, Yasin
dc.contributor.authorAslantaş, Yusuf
dc.contributor.authorAydın, Yusuf
dc.contributor.authorDemirin, Hilmi
dc.contributor.authorKutlucan, Ali
dc.contributor.authorTibilli, Hakan
dc.contributor.authorÖzhan, Hakan
dc.date.accessioned2020-05-01T12:10:18Z
dc.date.available2020-05-01T12:10:18Z
dc.date.issued2013
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000318664500005en_US
dc.descriptionPubMed: 23705556en_US
dc.description.abstractObjective Patients with diabetes mellitus (DM) are at an increased risk of sudden cardiac death (SCD) partly explained by cardiac autonomic neuropathy (CAN). There have been fewer studies to evaluate CAN using heart rate variability (HRV) and heart rate recovery (HRR) in patients with type 2 DM. To our knowledge, there has been no study to investigate the association between HRR, HRV and type 1 DM. The purpose of this study was to examine the changes in HRR and HRV measurements in type 1 diabetic patients. Methods The study population consisted of 35 consecutive patients with type 1 diabetes and 35 sex- and age-matched non-diabetic controls. We performed electrocardiography, echocardiography, Holter analysis, exercise stress test, routine biochemical tests including haemoglobin A1c, high-sensitivity C-reactive protein and evaluated the clinical characteristics. HRR was calculated by subtracting the heart rate values at the first minute of the recovery phase from the peak heart rate. Abnormal HRR was defined as HRR <= 18 beats. The HRV analysis was performed in both time domain and frequency domain. Results In HRV analysis, type 1 diabetic patients had significantly lower time domain [SDNN (P=0.041), SDANN (P=0.016), r-MSSD (P<0.001), pNN50 (P<0.001)] and frequency domain [total power (P=0.002), VLF (P<0.001), LF (P<0.001), HF (P=0.001), LF/HF (P=0.034)] HRV parameters as compared to controls. In logistic regression analysis, the HRR (OR 0.927, 95% Cl 0.872 to 0.985, P=0.014), METs (OR 0.562, 95% Cl 0.355 to 0.890, P=0.014), pNN50 (OR 0.729, 95% Cl 0.566 to 0.941, P=0.015) and HF (OR 0.952, 95% Cl 0.911 to 0.994, P=0.027) were independently associated with type 1 DM. Conclusion The results of this study showed that HRV parameters and HRR were significantly reduced in patients with type 1 versus healthy controls. We found that HRV parameters correlated with HRR in type 1 diabetic patients. There is a relationship between CAN and inflammation and also, there may be a relationship between CAN and intensive glycaemic control according to this study.en_US
dc.identifier.doi10.1080/AC.68.2.2967271en_US
dc.identifier.endpage150en_US
dc.identifier.issn0001-5385
dc.identifier.issn1784-973X
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage145en_US
dc.identifier.urihttps://doi.org/10.1080/AC.68.2.2967271
dc.identifier.urihttps://hdl.handle.net/20.500.12684/6131
dc.identifier.volume68en_US
dc.identifier.wosWOS:000318664500005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofActa Cardiologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHeart rate recoveryen_US
dc.subjectheart rate variabilityen_US
dc.subjecttype 1 diabetes mellitusen_US
dc.titleHeart rate variability and heart rate recovery in patients with type 1 diabetes mellitusen_US
dc.typeArticleen_US

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