Histological Investigation of the Effects of Tenoxicam on Pulmonary Complications of Pneumoperitoneum - Tenoxicam Reduces Lung Injuries Caused by Pneumoperitoneum

Basit Öğe Kaydı
dc.contributor.authorGezer, Suat
dc.contributor.authorKarapolat, Sami
dc.contributor.authorYıldırım, Ümran
dc.contributor.authorTürüt, Hasan
dc.contributor.authorErbaş, Mesut
dc.contributor.authorÖzaydın, İsmet
dc.date.accessioned2020-05-01T12:10:23Z
dc.date.available2020-05-01T12:10:23Z
dc.date.issued2011
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionTURUT, HASAN/0000-0002-9940-3787en_US
dc.descriptionWOS: 000296474800013en_US
dc.description.abstractObjectives. Pneumoperitoneum increases intra-abdominal pressure and generates oxidative stress, which mediates tissue injury. One of the causes of oxidative stress production is an inflammatory reaction. Taking this into consideration, the current animal study was designed, using tenoxicam before a laparoscopy procedure in order to ascertain whether tenoxicam can prevent lung injury caused by pneumoperitoenum. Material and Methods. Fourteen female Wistar rats were randomly divided into two groups: the tenoxicam group (seven rats) and the control group (seven rats). The tenoxicam group was given two doses (totalling 0.5 mg/kg) of intraperitoneal tenoxicam, and the control group was given 0.5 cc of 0.9% NaCl, 12 hours and 1/2 hour before the operation. Under intra-peritoneal anesthesia, a Veress needle was placed in the peritoneal cavity and a 15 mm-Hg pneumoperitoneum was established and maintained for 20 minutes; the peritoneal gas was then desufflated. The lungs were resected at the 180(th) minute from the beginning of the operation and were evaluated histopathologically. Histopathological evaluations including intra-alveolar hemorrhage, alveolar edema, congestion and leukocyte infiltration were carried out for both groups. Results. A statistical comparison of the evaluation scores revealed significant differences between the two groups for intra-alveolar hemorrhage (p = 0.007), alveolar edema (p = 0.023) and congestion (p = 0.005) and a nonsignificant difference for leukocyte infiltration (p = 0.114). Conclusions. Pneumoperitoneum causes injuries to lung tissue; tenoxicam reduces that damage and protects the lungs by decreasing intra-alveolar hemorrhage, alveolar edema and congestion (Adv Clin Exp Med 2011, 20, 4, 503-507).en_US
dc.identifier.endpage507en_US
dc.identifier.issn1899-5276
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage503en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/6174
dc.identifier.volume20en_US
dc.identifier.wosWOS:000296474800013en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWroclaw Medical Univen_US
dc.relation.ispartofAdvances In Clinical And Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectpneumoperitoneumen_US
dc.subjectlung injuryen_US
dc.subjecttenoxicamen_US
dc.subjectraten_US
dc.titleHistological Investigation of the Effects of Tenoxicam on Pulmonary Complications of Pneumoperitoneum - Tenoxicam Reduces Lung Injuries Caused by Pneumoperitoneumen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu