Synergistic effect of ZnO nanoparticles and hesperidin on the antibacterial properties of chitosan

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dc.authoridaksu, mecit/0000-0002-9864-727X
dc.authorwosidaksu, mecit/J-5404-2012
dc.contributor.authorErol, İbrahim
dc.contributor.authorHazman, Ömer
dc.contributor.authorAksu, Mecit
dc.contributor.authorBulut, Emine
dc.date.accessioned2023-07-26T11:54:13Z
dc.date.available2023-07-26T11:54:13Z
dc.date.issued2022
dc.departmentDÜ, Fen-Edebiyat Fakültesi, Kimya Bölümüen_US
dc.description.abstractIn this study, hesperidin (HSP) biological agent, which has strong antioxidant properties, was successfully transferred to ZnO nanoparticles, which were first synthesized by the hydrothermal method. Then, chitosan (CS)/ZnO-HSP nanocomposites were produced by adding different ratios of the ZnO-HSPs to the biodegradable CS biopolymer by hydrothermal method. The resulting materials were characterized using various biophysical strategies, including X-ray diffraction (XRD), Fourier transform infrared spectrometry, scanning electron microscopy (SEM), and energy dispersive X-ray spectroscopy. The mean particle size of ZnO was estimated to be 29 nm from the XRD calculations and SEM measurements. The effect of the ZnO-HSPs on the thermal properties of pure CS was investigated by thermogravimetric analysis and differential scanning calorimetry techniques, and improvements were noted in the thermal properties of CS. While the T-g value of CS was 81 degrees C, this value increased by 13-94 degrees C with the addition of 6 wt% by weight of the ZnO-HSP. The antibacterial effect of materials was determined by the disc diffusion method. The ZnO-HSPs added to the CS caused the nanocomposites to have a remarkable effect against Escherichia coli and Staphylococcus aureus microorganisms. While the inhibition diameter of the CS against E. coli was 18.3, the same value increased to 22.3 for the composite containing 6 wt% the ZnO-HSP. The HSP increased the antioxidant capacity of both the ZnO-HSP particles and the CS/ZnO-HSP nanocomposites, reducing the toxic effects of ZnO nanoparticles. Thus, it was determined that the CS/ZnO-HSP nanocomposites did not have any cytotoxicity in healthy human cells. The fact that the produced nanocomposites exhibit antibacterial activity and do not harm human cells shows that they can be a safe product for health. From all these results, this triple hybrid system is hoped that it will be used in biomedical applications as a naturally-sourced, environmentally friendly, and cost-effective composite biomaterial by combining its antimicrobial and strong antioxidant properties.en_US
dc.description.sponsorshipAfyon Kocatepe University Scientific Research Projects Coordination Unit [21-FENED-05]en_US
dc.description.sponsorshipThis study has been supported by the Afyon Kocatepe University Scientific Research Projects Coordination Unit. The Project Number is 21-FENED-05.en_US
dc.identifier.doi10.1080/09205063.2022.2099668
dc.identifier.endpage1997en_US
dc.identifier.issn0920-5063
dc.identifier.issn1568-5624
dc.identifier.issue15en_US
dc.identifier.pmid35797143en_US
dc.identifier.scopus2-s2.0-85134168607en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1973en_US
dc.identifier.urihttps://doi.org/10.1080/09205063.2022.2099668
dc.identifier.urihttps://hdl.handle.net/20.500.12684/12768
dc.identifier.volume33en_US
dc.identifier.wosWOS:000826031900001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorAksu, Mecit
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal of Biomaterials Science-Polymer Editionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectChitosan; Zno; Hesperidin; Nanocomposites; Biological Propertiesen_US
dc.subjectIn-Vitro; Antioxidant Capacity; Nanocomposites; Composite; Methacrylate; Particles; Powder; Chitinen_US
dc.titleSynergistic effect of ZnO nanoparticles and hesperidin on the antibacterial properties of chitosanen_US
dc.typeArticleen_US

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