Evaluation of Serum Soluble Lectin-like Oxidised Low-Density Lipoprotein Receptor-1 (sLOX-1) Level in Children with Non-Complicated Type-1 Diabetes Mellitus (T1DM) and Its Relationship with Carotid Intima Media Thickness (cIMT)

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dc.contributor.authorOzde, Sukriye
dc.contributor.authorYavuzyilmaz, Fatma
dc.contributor.authorOzel, Mehmet Ali
dc.contributor.authorKayapinar, Osman
dc.contributor.authorOzde, Cem
dc.contributor.authorAkture, Gulsah
dc.contributor.authorArslanoglu, Ilknur
dc.date.accessioned2025-10-11T20:47:47Z
dc.date.available2025-10-11T20:47:47Z
dc.date.issued2025
dc.departmentDüzce Üniversitesien_US
dc.description.abstractBackground: The objective of this study was to evaluate serum soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) levels in children with type-1 diabetes mellitus (T1DM) without any atherosclerotic complications and to investigate whether there was an association with early atherosclerotic processes in these children. Methods: The study's design entailed a prospective cross-sectional observational study methodology. The patient group consisted of 80 consecutive children aged 8-18 years who had been diagnosed with T1DM for at least ten years and had not developed any chronic clinical complications related to T1DM. The control group consisted of 72 completely healthy children with similar demographic characteristics. Serum levels of sLOX-1 were measured, and carotid intima-media thickness (cIMT) was evaluated using ultrasonography in all subjects. Results: A statistical analysis of the results was conducted. The serum sLOX-1 level was found to be significantly higher in the patient group than in the control group (0.49 +/- 0.11 vs. 0.82 +/- 0.35; p < 0.001). The statistical significance observed was maintained in the multivariable logistic regression analysis (p < 0.001). A significant correlation was identified between cIMT and serum sLOX-1 levels (r = 0.669, p < 0.001). The receiver operating characteristic curve for sLOX-1 indicated that a cutoff value greater than 0.65 ng/mL was associated with T1DM. Conclusions: Serum sLOX-1 levels were markedly elevated in children with T1DM who had not yet manifested chronic complications. These findings suggest that elevated serum sLOX-1 levels may be associated with the progression of atherosclerosis in children with T1DM.en_US
dc.description.sponsorshipDuezce University Scientific Research Projects coordination unit (DUEBAP) [2022.04.03-1309]en_US
dc.description.sponsorshipThis study was supported by Duezce University Scientific Research Projects coordination unit (DUEBAP Project number: 2022.04.03-1309).en_US
dc.identifier.doi10.3390/jcm14030935
dc.identifier.issn2077-0383
dc.identifier.issue3en_US
dc.identifier.pmid39941605en_US
dc.identifier.scopus2-s2.0-85217693050en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3390/jcm14030935
dc.identifier.urihttps://hdl.handle.net/20.500.12684/21561
dc.identifier.volume14en_US
dc.identifier.wosWOS:001420306200001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofJournal of Clinical Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_WOS_20250911
dc.subjecttype-1 diabetes mellitus (T1DM)en_US
dc.subjectsoluble lectin-like oxidized low-density lipoprotein receptor 1 (sLOX-1)en_US
dc.titleEvaluation of Serum Soluble Lectin-like Oxidised Low-Density Lipoprotein Receptor-1 (sLOX-1) Level in Children with Non-Complicated Type-1 Diabetes Mellitus (T1DM) and Its Relationship with Carotid Intima Media Thickness (cIMT)en_US
dc.typeArticleen_US

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