Are there any effects of chronic carbon monoxide exposure on argyrophilic nucleolar-organizing region-associated protein synthesis in rat myocardium?

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dc.contributor.authorSarıtaş, A.
dc.contributor.authorGüneş, Harun
dc.contributor.authorÇolakoğlu, Serdar
dc.contributor.authorEröz, Recep
dc.contributor.authorAköz, Ayhan
dc.contributor.authorOktay, Murat
dc.contributor.authorÖzkan, A.
dc.date.accessioned2020-04-30T22:39:38Z
dc.date.available2020-04-30T22:39:38Z
dc.date.issued2016
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000381951900002en_US
dc.descriptionPubMed: 26462711en_US
dc.description.abstractThe aims of the study are to detect whether there are any possible effects of chronic carbon monoxide (CO) exposure on the argyrophilic nucleolar-organizing region (AgNOR)-associated protein synthesis and evaluate any possible relationship between the amount of AgNOR protein and the level of myocardial injury also and between AgNOR and histopathological evaluation methods. Adult male albino Wistar rats (n = 18) were randomly divided into three groups (groups A, B, and C). Group A served as control, while groups B and C were rats exposed to CO gas chrbnically (1000 and 3000 ppm CO concentration with a flow rate of 4 L/min for 30 min/day for 7 days, respectively). Total AgNOR area/nuclear area (TAA/NA) and the mean AgNOR numbers for each myocyte nucleus were determined. There were significant differences among all groups for TAA/NA ratio. These differences were not significant for mean AgNOR numbers. According to the histopathological evaluation scores, there were significant differences between the groups. The differences were significant among the groups for loss of sarcomere pattern. A strong positive correlation between histopathological injury scores and TAA/NA ratio was found (R-sq = 0.48; p = 0.002), however, the correlation was not significant for mean AgNOR numbers (R-sq = 0.08; p = 0.25). In conclusion, TAA/NA ratio can be used as an indicator for obtaining information about the level of myocardial damage instead of histopathological evaluation scores.en_US
dc.identifier.doi10.1177/0960327115608929en_US
dc.identifier.endpage928en_US
dc.identifier.issn0960-3271
dc.identifier.issn1477-0903
dc.identifier.issue9en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage921en_US
dc.identifier.urihttps://doi.org/10.1177/0960327115608929
dc.identifier.urihttps://hdl.handle.net/20.500.12684/2784
dc.identifier.volume35en_US
dc.identifier.wosWOS:000381951900002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofHuman & Experimental Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChronic carbon monoxide intoxicationen_US
dc.subjectAgNORen_US
dc.subjectmyocardiumen_US
dc.titleAre there any effects of chronic carbon monoxide exposure on argyrophilic nucleolar-organizing region-associated protein synthesis in rat myocardium?en_US
dc.typeArticleen_US

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